揭阳市b型流感嗜血杆菌结合疫苗 (Hib) 预防接种不良反应监测分析.docVIP

揭阳市b型流感嗜血杆菌结合疫苗 (Hib) 预防接种不良反应监测分析 张冬生 黄宏龙 郑良忠 林伟波 谢培鹏 揭阳市疾病预防控制中心 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 分析揭阳市b型流感嗜血杆菌结合疫苗预防接种不良反应数据, 评价其接种后的安全性, 为在全市推广应用, 制订免疫程序提供科学依据。方法 汇总揭阳市60多家预防接种门诊上报的1.5万针次的Hib结合疫苗儿童预防接种后发生的不良反应现场观察和主动性回访监测数据, 采用描述性流行病学分析方法。结果 接种后总的不良反应发生率较低, 为3.0%;且表现轻微, 均可在72 h内恢复;其中弱、中、强反应率分别为1.4%、1.2%、0.5%, 各组反应率比较差异无统计学意义 (P0.05) ;局部反应率为2.1%;2448 h两个回访时间段发生发热反应的人群差异无统计学意义 (P0.05) 。结论 Hib结合疫苗安全性较高, 接种后未监测到严重的不良反应发生, 加强接种后的不良反应监测, 及时处置发生的异常反应。 关键词： b型嗜血杆菌结合疫苗; 预防接种; 不良反应; 作者简介：张冬生, 学士, 主管医师, 从事疫苗针对传染病预防控制工作, E-mail:zhangdongsheng1228@163.com 收稿日期：2017-03-17 Analysis of adverse reacti of haemophilus type b conjugate vaccine vaccination in Jieyang ZHANG Dongsheng ZHENG Liangzhong YANG Yonghong LIN Weibo XIE Peipeng Jieyang Center for Disease Control and Prevention; Abstract： Objective Analysis of Jieyang City type Haemophilus b conjugate vaccine adverse events following immunization data to evaluate its safety after vaccination, In order to promote the use of immunization programs in the city to provide a scientific basis. Methods Summary over 60 Jieyang prevention 15 000 times Hib vaccination clinics reported binding site adverse reactions after vaccination vaccine child observation and monitoring initiatives returning data, descriptive epidemiological analysis. Results After inoculation overall incidence of adverse reactions was low as3.0 %; and exhibits a slight, can be recovered within 72 hours; wherein the weak, the strong response rates were 1.4 %, 1.2 %, 0.5 %, respectively, each set of reaction rate difference was not statistically significant (P 0.05) ; partial response rate of 2.1 %;there was no statistically significant difference between the two groups at 24 to 48 hours. Conclusion Hib conjugate vaccine safety is high, not monitored after vaccination to serious adverse events, strengthen monitoring of adverse reactions after vaccination, timely disposal abnormal reaction occurred. Keyword：