手足口病患儿血清循环脱氧核糖核酸与C反应蛋白水平变化及意义.docVIP

手足口病患儿血清循环脱氧核糖核酸与C反应蛋白水平变化及意义.doc

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手足口病患儿血清循环脱氧核糖核酸与C反应蛋白水平变化及意义

精品论文 参考文献 手足口病患儿血清循环脱氧核糖核酸与C反应蛋白水平变化及意义 刘玲玲   (商丘市第一人民医院分院检验科, 河南 商丘 476100)   [摘要]目的:分析手足口病(HFMD)患儿血清循环脱氧核酸(cfDNA)与C反应蛋白水平(CRP)的变化及意义。方法:选择2013年10月-2014年11月来我院治疗手足口病的患儿35例作为研究组,同期选择35例健康儿童作为对照组,观察两组患儿血清循环脱氧核酸和C反应蛋白水平变化。结果:研究组患儿的血清循环脱氧核酸与C反应蛋白水平均明显高于对照组儿童,差异有统计学意义(P<0.05)。研究组患儿的血清循环脱氧核酸与C反应蛋白水平均随着病情的加重逐渐升高;血清循环脱氧核酸与C反应蛋白水平呈正相关。结论:手足口病患儿的血清循环脱氧核酸与C反应蛋白水平均明显高于健康儿童,临床医生可以将血清循环脱氧核酸与C反应蛋白水平作为判断手足口病患儿的病情和预后指标。   [关键词]手足口病;血清循环脱氧核酸;C反应蛋白水平;相关性   Changes of serum circulating DNA and C reactive protein in children with hand foot mouth disease and its significance   Liu Lingling (Department of laboratory Shangqiu First Peoples Hospital Henan branch Shangqiu 476100)   Objective: to analyze the changes and significance of serum circulating DNA (cfDNA) and C reactive protein (CRP) in children with hand, foot and mouth disease (HFMD). Methods: 35 children with hand, foot and mouth disease in our hospital from October 2013 to November, were selected as study group, and 35 healthy children were selected as the control group. The levels of serum circulating DNA and C reactive protein in the two groups were observed. Results: the levels of serum circulating DNA and C reactive protein in the study group were significantly higher than those in the control group (P lt; 0.05). The levels of serum circulating DNA and C reactive protein in the study group were increased with the increase of the severity of the disease, and serum circulating DNA was positively correlated with the level of C reactive protein. Conclusion: the serum levels of circulating DNA and C in children with hand foot and mouth disease were significantly higher than those in healthy children, and the clinical doctors can be used to determine the level of serum circulating DNA and C reactive protein as a marker of disease and prognosis in children with hand foot and mouth disease.   Keywords hand foot mouth disease; serum circulating DNA; C reactive protein level; correlation   手足口病(HFMD)是由于肠道病毒感染引起的传染病,一般是儿童的多发病[1]。临床症状为

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