头孢硫脒与加替沙星对革兰阳性球菌的联合药敏研讨.pdfVIP

头孢硫脒与加替沙星对革兰阳性球菌的联合药敏研究 裴斐 郭代红 常红霞 孙映和 王睿 解放军总医院药材处 北京100853 摘要 评价头孢硫脒分别与加替沙星联合用药 对于临床分离的革兰阳性球菌 包括金黄色葡萄球菌 Staphylococcus aureus SA 表皮葡萄球菌(Staphylococcus epidermidis SE) 和粪肠球菌(Enterococcus faecalis Ef) 的体外联合抗菌效应 采用棋盘法设计 微量肉汤稀释法测定 测定不同浓度组合的六组抗菌 药物对90 株临床分离的革兰阳性球菌的最低抑菌浓度 并计算FIC 指数判定联合效应 FIC 0.5为协同作 用 0.5FIC 1为相加作用 1FIC2为无关作用 FIC2 为拮抗作用 头孢硫脒与加替沙星联合应用后 其MIC50 显著降低 FIC 指数分布 FIC 0.5 占60%~86.7% 0.5FIC 1占13.3%~23.3% 1FIC2占0~13.3% FIC2 为0 结果表明加替沙星与头孢硫脒联合用药后 对革兰阳性球菌基本表现为协同作用和相加作用 并 以协同作用为主 无关作用较少 无拮抗作用 关键词 头孢硫脒 革兰阳性球菌 联合药敏 The study on the antibacterial activity of cefathiamidine combine with gatifloxacin against Gram-positive cocci Guo Daihong Sun Yinghe Pei Fei Wang Rui The Chinese PLA General Hospital Beijing 100853 Abstract: OBJECTIVE To evaluate the antibiotic effects of cefathiamidine combine with gatifloxacin against 90 strains of Grams positive cocci. METHOD The protocol was designed by checkerboard method and the MICs of cefathiamidine alone and combined with gatifloxacin against the 90 strains of Gram positive cocci were determined by broth dilution method the FIC index was calculated according to MIC results. RESULTS The MIC50 of cefathiamidine were reduced significantly when combined with gatifloxacin. The percentage of the FIC index less than 0.5 from 0.5 to 1 from 1 to 2 more than 2 was 60%~86.7% 13.3%~23.3% 0~13.3% and 0% respectively. CONCLUSION The results suggested that synergism and additivity of cefathiamidine combine with gatifloxacin against 90 strains of Gram positive cocci were main action there were little autonomy and no antagonism. Key words: cefathiamidine gatifloxa