探讨血脂异常与冠心病及冠心病合并高血压的相关性.docVIP

精品论文 参考文献 探讨血脂异常与冠心病及冠心病合并高血压的相关性 黑龙江省海员总医院 150026 【摘 要】目的 研究分析血脂异常与冠心病及冠心病合并高血压的相关性。方法 此次研究的对象是选取我院心血管内科2013年10月～2014年9月门诊、住院、体检患者，选择其中确诊为高血压合并冠心病患者120例、单纯高血压病患者120例、正常人群120例。采用血压测量和血脂测量的方法对患者进行研究。结果 在单纯冠心病患者中apoA和apoA/apoB的值显著低于健康人组，apoB的值显著高于健康人组。在冠心病合并高血压组中apoA和apoA/apoB的值显著低于健康人组，apoB的值显著高于健康人组。结论 当健康人发展为冠心病时，再进一步发展为冠心病合并高血压时，apoA的持续降低及apoB的持续增高。 【关键词】血脂；冠心病；高血压 [Abstract] Objective To study the relationship between abnormal blood lipid and coronary heart disease and coronary heart disease complicated with hypertension. Methods the research object is selected cardiovascular department of our hospital in October 2013 to 2014 September outpatient，hospitalization，medical patients，which diagnosed hypertension merge in patients with coronary heart disease（CHD）in 120 cases，120 cases of simple hypertension patients and normal population of 120 cases. Methods of blood pressure measurement and blood lipid measurement were used to study the patients. Results the values of apoA and apoA/apoB in patients with simple CHD were significantly lower than those in the healthy group，and the value of apoB was significantly higher than that of the healthy group. The value of apoA and apoA/apoB in the coronary heart disease complicated with hypertension group was significantly lower than that of the healthy group，and the value of apoB was significantly higher than that of the healthy group. Conclusions when the healthy people develop coronary heart disease，and then the further development of coronary heart disease combined with hypertension，apoA continued to decrease and the continuous increase of apoB. [Key words] blood lipid；coronary heart disease；hypertension 血脂异常是心血管系统最重要的危险因素之一。近年研究显示，血脂异常的患者即使经过大剂量他汀类药物强化降胆固醇治疗后仍面临很高的心血管剩留风险[1]。在心血管病患者中，甘油三酯（TG）升高和高密度脂蛋白胆固醇（HDL-C）降低是构成心血管剩留风险的主要血脂异常表型[2]。迄今为止，大量临床发现，即使在低密度脂蛋白（LDL）降低至正常后，仍然会发生冠心病和动脉粥样硬化。 动脉粥样硬化是动脉硬化血管病中最常见、最重要的一种，动脉硬化血管病的共同特点是动脉管壁变硬失去弹性和官腔缩小，导致其顺应性较小，大动脉的弹性贮器作用减弱，动脉压增大，即：收缩压更高，舒张压更低。 高血压是冠心病的独立危险因素，并与