糖尿病肾病易感因素的综合研究A Comprehensive Study of Susceptibility to Diabetic Nephropathy.pdfVIP

提 要 目的：分析和总结糖尿病肾病发生的易感因素，为进一步制定相关的预防措施和 治疗方案提供依据，以期阻止或延缓糖尿病肾病的的发展。 方法：从山东中医药大学附属医院、山东中西医结合医院、山东省立医院三家医 院搜集207例糖尿病和早期糖尿病肾病患者的病例资料，收集患者的年龄、性别、身 高、体重、腰围、血压、血脂、血糖、吸烟、饮酒、饮食和体质等临床资料及相关病 史资料，根据患者24h尿蛋白定量或晨尿微量白蛋白定量将患者分为微量蛋白尿组和 正常蛋白尿组，对各组资料进行相关性分析，采用 logistic 回归分析糖尿病肾病发 生的易感因素。 结果：经过分析发现年龄、糖尿病病程、收缩压、舒张压、总胆固醇、高血压病 史、空腹血糖、糖尿病家族史、糖尿病眼病、吸烟史与糖尿病肾病的发生有显著相关 性，有临床意义；经logistic回归分析发现性别、糖尿病病程、收缩压、空腹血糖、 糖尿病家族史、糖尿病眼病和吸烟史是糖尿病肾病发病的易感因素。 结论：糖尿病肾病的发生是多种因素共同作用的结果，糖尿病病程、收缩压、空 腹血糖、糖尿病家族史、糖尿病眼病和吸烟史是糖尿病肾病发生的易感因素，性别、 体质和饮食等因素对糖尿病肾病发病的影响有待进一步研究。 关键词 糖尿病；糖尿病肾病；易感因素 Study on Predisposing Factors of Diabetic Nephropathy Specialty：Internal Medicine of Traditional Chinese Medicine Author ：Xiao juan Tutor：Professor Guo Zhao an Abstract Objective:To provide a basis for working out pertinent preventive measures and therapeutic schedules,the study analysised and summaried the predisposing factors of Diabetic Nephropathy so as to prevent or delay the development of diabetic nephropathy. Methods: Collected 207 cases of diabetes and early the diabetes nephrosis patient cases material from shandong university of traditional Chinese medicine hospital, shandong medicine hospital, shandong province hospital three hospitals ，the study collected the patients’ age, sex, height, weight, waist circumference, blood pressure, blood lipids , blood glucose, smoking, alcohol consumption, diet, constitution and medical history data and so on. Divided the patients into Microalbuminuria group and Normal albuminuria group according to their 24h urine protein quantitative or urine albumium excretion rate in order to the correlation analysis. And summarized the predisposin