某医院原发性醛固酮增多症的诊断情况分析.docVIP

精品论文 参考文献 某医院原发性醛固酮增多症的诊断情况分析 李强1 崔巍2 唐蕾1（1 成都大学附属医院内分泌科 610081 ； 2 西安交通大学第一附属医院内分泌科 710061） 　　【摘要】目的：回顾性分析原发性醛固酮增多症（Primary hyperaldosteronism PA）病人的临床资料和特点，为PA 的诊断提供参考。方法：收集西安交通大学附属第一医院2010 年—2013 年期间确诊PA 病人病历资料进行分析。结果：确诊PA 的51 例中男性20 例（39.2%），女性31 例(60.8%)，其中特发性醛固酮增多症12 例(23.5%)，醛固酮瘤39 例(76.5%)。两组患者高血压病程均明显大于低钾血症病程（P＜0.05），血钾、血管紧张素II 降低，醛固酮水平升高，两组无显著差异（P＞0.05）。结论：原发性醛固酮增多症患者低钾血症可出现在高血压病之后数年，对不伴有低钾血症的PA 诊治需加以重视，争取早期诊断。醛固酮瘤是PA 主要病因，血钾、血管紧张素II、醛固酮水平可能不能作为病因鉴别诊断依据。 　　【关键词】原发性醛固酮增多症；特发性醛固酮增多症；醛固酮瘤【中图分类号】 R2 【文献标号】 A 【文章编号】 2095-7165（2015）11-0022-02Analysis of diagnosis of Primary hyperaldosteronism in a hospitalLiqiang1，Cuiwei2，Tanglei11Department of Endocrinology, the Affiliated Hospital of Chengdu University；2Department of Endocrinology, the First Affiliated Hospitalof Xian Jiao Tong University,Abstract：Objective To provide reference for diagnosis of Primary hyperaldosteronism(PA) the clinical data and characteristics of PA retrospectivelyanalyzed. Methods: the records of PA patients from the First Affiliated Hospital of Xian Jiao Tong University during 2010 to 2013 were analyzed..Results: 20 of 51 patients (39.2%) were male, 31 (60.8%) were female, 12 (23.5%) were idiopathic hyperaldosteronism and 39(76.5%) wereAldosterone-producing-adenomas.The course of hypertension in the two groups was significantly longer than that of low potassium (P lt; 0.05). Bloodpotassium, angiotensin II was decreased, and aldosterone levels were elevated, there was no significant difference between the two groups (P gt; 0.05).Conclusion: The symptoms of low serum potassium in PA may occurred several years after hypertension, so PA with no low serum potassium needed to bepaid more attention . Aldosterone-producing-adenomas is the main cause of PA, and serum potassium, angiotensin II and aldosterone may not be the basisfor etiological diagnosis..Key words: Idiopathic hyperaldosteronism; Idiopathic hyperaldosteronism; Aldosterone-producing-adenomas 　　原发性醛固酮增多症是指肾上腺皮质病变所致醛固酮分泌增多、肾素-血管紧张素系统受