格列美脲联用甘精胰岛素或中性鱼精蛋白锌胰岛素治疗2 型糖尿病的临床对比观察.docVIP

精品论文 参考文献 格列美脲联用甘精胰岛素或中性鱼精蛋白锌胰岛素治疗2 型糖尿病的临床对比观察 贾维敏 黄慧华 （安徽省第二人民医院黄山路院区普内科 230001） 【摘要】目的 比较格列美脲联用甘精胰岛素(IG)或中性鱼精蛋白锌胰岛素（NPH）对2型糖尿病（T2DM）患者的临床疗效及安全性。方法 96例血糖控制不佳的T2DM患者随机分为格列美脲联用IG治疗组（45例）或NPH治疗组（41例），两组治疗期间根据血糖水平调整用药剂量，比较两组血糖控制情况、疗效和安全性。结果 96 例T2DM患者均进行24周治疗，两组治疗后血糖指标较治疗前均明显改善（P lt;0.05，P lt;0.01），治疗后两组各指标的组间比较差异无统计学意义（Pgt;0.05），但IG组低血糖发生率显著低于NPH组（P lt;0.05)。结论 格列美脲联用IG或NPH可很好控制T2DM患者血糖，两者疗效相似，但格列美脲联用IG治疗T2DM更为安全、有效。 【关键词】 2型糖尿病 格列美脲 甘精胰岛素 中性鱼精蛋白锌胰岛素 【中图分类号】R587.1 【文献标识码】A 【文章编号】2095-1752（2013）25-0090-02 Clinical effect of glimepiride combined insulin glargine or neutral protamine hagedorn on type 2 diabetes mellitus 【Abstract】 0bjective：To compare the clinical therapeutic effects of glimepiride combined with insulin glargine (IG) or neutral protamine hagedorn (NPH) respectively on type 2 diabetes mellitus (T2DM) patients.Methods：Ninety-sixes patients of T2DM in plasma glucose poorly controlled with treatment of glimepiride combined with IG（IG group, 45 cases）or NPH （NPH group, 41 cases）.The changes of plasma glucose levels before and after the treatment were compared and evaluated between IG group and NPH group.Results：By 24 weeks，the mean value of plasma glucose levels in IG group and NPH group decreased (Plt;0.05, Plt;0.01)，but there were no significant difference at efficacy between the two groups(Pgt;O.05).Compared with NPH group, the numbers of incidence of hypoglycemia decreased significantly in IG group (Plt;0.05).Conclusions：The patients with T2DM plasma glucose poorly controlled can be well controlled with treatment of glimepiride and injection of IG or NPH.The efficacy of injection with IG or NPH is similar，but treatment with IG is lower in incidence of hypoglycemia， thus safe and effective treatment than NPH. 【Key words】 type 2 diabetes mellitus glimepiride glargine neutral protamine hagedorn 第三代磺酰脲类抗糖尿病药格列美脲（glimepiride）具有抑制肝葡萄糖合成、促进肌组织对外周葡萄糖的摄取和刺激胰岛B细胞分泌胰岛素的作用，现已广泛用于单纯饮食控制和锻炼未能有效控