TP及CAP化疗方案治疗晚期卵巢癌的比较.doc

TP及CAP化疗方案治疗晚期卵巢癌的比较 【关键词】 CAP化疗 【摘要】 目的 探讨进口紫杉醇与顺铂联合化疗方案（TP）治疗晚期卵巢癌的疗效及毒性作用。 方法 对1996年1月～2003年6月采用TP化疗方案治疗的晚期卵巢癌患者进行回顾性分析，并与环磷酰胺（C）、阿霉素（A）及顺铂（P）联合化疗方案（CAP）进行比较。TP组20例，CAP组36例。 结果 TP组有效率75.0%，CAP一线用药有效率38.9%，两组间差异有非常显著性（P0.01）。TP组的不良反应在骨髓抑制、消化道症状、肝肾损害方面小于CAP组，在肌肉痛、手足麻木方面大于CAP组，两组间差异有显著性（P0.05）。而口腔炎、脱发、发热、面部潮红两组间差异无显著性（P0.05）。 结论 TP作为治疗晚期卵巢癌一线用药疗效高于CAP，而且毒副作用小，推荐作为治疗晚期卵巢癌的一线方案。 关键词 晚期卵巢癌 紫杉醇 毒性作用 Comparison of combination therapy with TP and CAP in treatment ofadvanced ovarian carcinoma Liu Junbao，Leng Weichun，Zhang Aichen，et al. Department of Obstetrics and Gynecology，China-Japan Union Hospital of Jilin University，Changchun130031. 【Abstract】 Objective To study effect and toxicities of paclitaxel combined with platinum（TP）in the treat-ment of advanced ovarian carcinoma.Methods A retrospective analysis in the treatment of advanced ovarian carcino-ma with TP from January1996to June2003was done，compared with the combination of cyclophosphamide，adri-amycin and platinum（CAP）.20patients in TP group，36patients in CAP group were analyzed.Results The effec-tive rate in TP group was75.0%，whereas the effective rate in CAP group was41.7%，there were obvious differ-ences between two groups（P0.01）.There were myelosuppression，nausea，vomiting and dysfunction of liver and kidney in the side-effects of TP group.The side-effects of TP group was slighter than the CAP groups myalgia，numb hands and feet in TP group was stronger than the CAP groups.There were differences in the effect between two groups（P0.05）.There was no differences in response of stomatitis，alopecia，fever and flush between two groups（P0.05）.Conclusion TP is clinically more effective than CAP in first line chemotherapy for the treatment of ad-vanced ovarian carcinoma，and toxicities was slight.It is recommended to be first-line chemotherapy. Key words advanced ovarian carcinoma Paclitaxel toxicities 卵巢癌是女性生殖器三大恶性肿瘤之一，5年生存率为30%～40%，是妇科恶性肿瘤中死亡率最高的疾病 ［1］ 。晚期卵巢癌的治疗仍是肿瘤细胞减灭术术后联合化疗，而化疗在治疗晚期卵巢癌中起着非常重要的作用。以往多采用环磷酰胺（C）、阿霉素（A