哌拉西林与加替沙星联合对铜绿假单胞菌的联合药敏研讨.pdfVIP

哌拉西林与加替沙星联合对铜绿假单胞菌的联合药敏研究 任浩洋 周筱青 裴斐 王睿 柴栋 方翼 解放军总医院药材处 北京100853 摘要 评价哌拉西林与加替沙星联合用药 对30 株临床分离的铜绿假单胞菌的体外联合抗 菌效应 采用棋盘法设计 微量肉汤稀释法测定 测定不同浓度组合的抗菌药物对30 株临 床分离的铜绿假单胞菌的最低抑菌浓度 并计算FIC 指数判定联合效应 FIC 0.5为协同 作用 0.5FIC 1为相加作用 1FIC2为无关作用 FIC2 为拮抗作用 哌拉西林与加 替沙星联合应用后 其MIC50 显著降低 FIC 指数分布 FIC 0.5 占40% 0.5FIC 1占 50% 1FIC2占10% FIC2 为0 结果表明加替沙星与哌拉西林联合用药后 对铜绿假 单胞菌基本表现为协同作用和相加作用 并以协同作用为主 无关作用较少 无拮抗作用 关键词 哌拉西林 加替沙星 铜绿假单胞菌 联合药敏 The study on the antibacterial activity of piperacillin combine with gatifloxacin against Pseudomonas aeruginosa Ren Haoyang Zhou Xiaoqing Pei Fei Wang Rui Chai Dong Fang Yi 2 The Dept. of clinical pharmacology of Chinese PLA General Hospital Beijing 100853 ABSTRCT: To evaluate the antibiotic effects of piperacillin combined with gatifloxacin against 30 strains of Pseudomonas aeruginosa . The protocol was designed by checkerboard method and the MICs of piperacillin or/and combined with other 6 antibiotics against the 30 strains of Pseudomonas aeruginosa were determined by broth dilution method , the FIC index was calculated according to MIC results. The percentage of the FIC index less than 0.5, from 0.5 to 1, from 1 to 2, more than 2 was 40%, 50%, 10%, 0% respectively. The results suggested that synergism and additivity of piperacillin c ombined with gatifloxacin respectively against 30 strains of Pseudomonas aeruginosa were main action , there were little autonomy and no antagonism. KEY WORDS: piperacillin gatifloxacin Pseudomonas aeruginosa FIC [1] 据中国医院内病原菌耐药监测网住院感染患者分离菌的报道 铜绿假单胞菌是院内 感染主要致病菌之一 约占 10~20% 在中国重症监护病房中分离的革兰阴性菌中 铜绿假 单胞菌位列第一位 由于具有天然和获得性耐药性 铜