氯吡格雷治疗急性脑梗死的临床疗效及安全性观察.docVIP

精品论文 参考文献 氯吡格雷治疗急性脑梗死的临床疗效及安全性观察 周蕊 黄全胜 王海州(徐州市肿瘤医院/徐州市第三人民医院 江苏徐州 221004) 【摘要】目的 观察氯吡格雷在急性脑梗死治疗中的临床疗效及安全性。方法 将我科室2011年1月至2012年6月收治的急性脑梗死病人50例随机分为两组，在常规治疗基础上,观察组为加用氯吡格雷,对照组加用肠溶阿司匹林,观察治疗2周后的两组临床疗效,神经功能缺损评分及不良反应的发生。结果 治疗2周后,两组神经功能缺损评分NIHSS评分均明显降低(p＜0.05),观察组评分降低程度明显优于对照组，且差异有显著性(p＜0.05)。观察组的总有效率明显高于对照组(p＜0.05),治疗过程中观察组无明显不良反应，对照组发生消化道反应3例，均无明显出血等严重不良反应发生。结论 氯吡格雷治疗急性脑梗死疗效确切，且安全性可靠。 【关键词】氯吡格雷 急性脑梗死 疗效观察 安全性 【中图分类号】R969【文献标识码】A【文章编号】2095-1752（2012）32-0164-01 ZhouRui HuangQuanSheng WangHaiZhou Xuzhou tumour hospital (xuzhou the third peoples hospital) 【Abstract】Objective: to observe the clinical curative effect and security of clopidogrel in the acute cerebral infarction. Methods: 50 cases of patients with acute cerebral infarction between January 2011 and June 2012 randomly divided into observation group and control group, the observation group (25 cases) received clopidogrel combined with conventional treatment；The control group (25 cases) received enteric aspirin combined with conventional treatment. The nerve function defect score scores ( NIHSS) and the adverse events are observed 2 weeks later .The result: NIHSS of the observation group were lower than that of the control group significantly, (plt; 0.01). The observation group total effective rate was obviously higher than that of the control group (plt; 0.01). No obvious adverse reaction occurred in patients of the observation group during the process of treatment, while gastrointestinal reaction occurred in 3 patients of the control group. Both groups have no obvious bleeding and other serious adverse reaction. Conclusion: the curative effect of clopidogrel in acute cerebral infarction is definite, safety and reliable. 【Key words】clopidogrel acute cerebral infarction curative effect observation safety 近年来脑血管意外已逐渐成为危害人类身体健康的头号杀手，致死率及致残率均居各种疾病的第一位，严重影响了患者的生活质量，给社会及家庭带来了极大的负担。脑梗死占脑血管意外的70%左右，故有效的脑梗死治疗及预防显得尤为迫切和必要。抗血小板聚集在脑梗死的治疗及预防中占有重要的位置。常用的抗血小板聚集剂包括阿司匹林和氯