氯沙坦对肺源性心脏病右心功能影响的研究.docVIP

精品论文 参考文献 氯沙坦对肺源性心脏病右心功能影响的研究 颜崇平 高友淑 孙向阳（四川省达州市中心医院心内科 635000） 【摘要】目的 对比研究应用氯沙坦和一般治疗对肺源性心脏病患者右心功能的影响。方法 将78例肺心病患者随机分为两组。对照组（n=39）给予肺心病常规治疗，氯沙坦组（n=39）给予常规治疗基础上加用氯沙坦治疗。于治疗前及治疗后6周分别测定肺通气功能、用力肺活量（FVC）、ls用力呼气容积（FEV1）和最大呼气流量（PEF）及超声测定右室流出道内径、右心室内径、右心肺动脉内径。结果 氯沙坦治疗后肺功能明显改善，右心内径及肺动脉内径，右室流出道内径小于治疗前，亦明显小于一般治疗组治疗后。结论 氯沙坦不仅能改善肺通气功能，亦能明显改善肺血管及右心室重构，减轻肺血管阻力。 【关键词】 氯沙坦 肺病 心功能 【中图分类号】R96 【文献标识码】A 【文章编号】2095-1752（2013）26-0114-02 Effects of losartan on pulmonary heart disease effects of right ventricular function Yan Chongping ,Gao Youshu , Sun Xingyang. Sichuan Dazhou town center hospital heart internal medicine department 635000 【Abstract】 Objective Comparison of losartan and the general treatment of pulmonary heart disease on right ventricular function. Methods 78 patients with pulmonary heart disease were randomly divided into two groups. The control group (n \u003d 39) given conventional therapy pulmonary heart disease, losartan group (n \u003d 39) received conventional therapy based on the use of losartan. In the treatment of 6 weeks before and after treatment were measured lung function, forced vital capacity (FVC), ls forced expiratory volume (FEV1) and peak expiratory flow (PEF) and ultrasound measurements of right ventricular outflow tract diameter, right ventricular diameter, right heart pulmonary artery. Results Losartan significantly improved lung function, right ventricular diameter and pulmonary artery, right ventricular outflow tract diameter is less than before treatment, but also significantly less than the general group after treatment. Conclusion Losartan not only improve pulmonary function also improved pulmonary vascular and right ventricular remodeling and reduce pulmonary vascular resistance. 【Keywords】 Losartan Disease Heart function 在心血管疾病中，氯沙坦的作用已从多方面得到循证医学的有力支持。本课题旨在研究氯沙坦对肺源性心脏病右心功能及右心结构的影响并对可能的机制进行探讨。现报告如下： 一、对象与方法 1.对象：选择2007年2月～2008年2月我科住院病人符合肺心病诊断者78例（