浅析慢性脑供血不足患者局部脑血流异常与认知功能障碍的关系.docVIP

精品论文 参考文献 浅析慢性脑供血不足患者局部脑血流异常与认知功能障碍的关系 大庆油田总医院 163000 　　摘要：目的 研究分析慢性脑供血不足患者局部脑血流异常与认知功能障碍的关系。方法 此次研究的对象是选择本院收治的慢性脑供血不足患者30例，将其临床资料进行回顾性分析，并选择同期健康体检者30例为对照组，采用简易智能状况量表（MMSE）、画钟表测验（CDT）、Fild物体记忆测验（FOM）评定两组认知功能；全部对象行多层螺旋CT脑灌注成像，采用感兴趣区（ROI）方法观察大脑各部位局部脑血流量（rCBF），并进行组间比较，分析患者各项认知功能评分与rCBF的关系。结果 研究组MMSE、CDT、FOM评分明显低于对照组，差异均有统计学意义（Plt;0.05）；研究组额叶、颞叶、顶叶、丘脑、小脑、脑干rCBF明显低于对照组，差异有统计学意义（Plt;0.05）；两组枕叶、基底节rCBF比较差异无统计学意义（Pgt;0.05）；慢性脑供血不足患者MMSE评分与颞叶、顶叶rCBF呈正相关（r=0.472、0.358，Plt;0.05），CDT评分与额叶、顶叶rCBF呈正相关（r=0.349、0.451，Plt;0.05）；FOM评分与颞叶、顶叶rCBF呈正相关（r=0.317、0.325，Plt;0.05）。结论 慢性脑供血不足患者存在不同程度的认知功能障碍，认知功能障碍程度与rCBF相关，可见相关区域rCBF减少可能是导致认知功能障碍的重要原因，临床应及早干预。 　　关键词：慢性脑供血不足；认知功能障碍；脑血流量 　　[Abstract]Objective To study the relationship between regional cerebral blood flow abnormalities and cognitive dysfunction in patients with chronic cerebral circulation insufficiency.The object of this research method is selected in our hospital 30 cases of patients with chronic cerebral insufficiency，the clinical data were retrospectively analyzed，and 30 cases of healthy people were selected as control group，using the Mini Mental Status Scale（MMSE）and clock drawing test（CDT），Fild object memory test（FOM two）function group cognitive assessment; all CT cerebral perfusion imaging object，using region of interest（ROI）method to observe the brain regional cerebral blood flow（rCBF），and comparison between groups，analysis of the relationship between the scores of cognitive function in patients with rCBF.Results MMSE，CDT，FOM score was significantly lower than the control group，the differences were statistically significant（Plt;0.05）; group of frontal lobe，temporal lobe，thalamus，cerebellum and brainstem rCBF was significantly lower than the control group，the difference was statistically significant（Plt;0.05）; the two groups had no statistical significance in occipital lobe and basal ganglia（rCBF difference Pgt;0.05）; chronic cerebral insufficiency associated with MMSE score in patients with temporal lobe rCBF positive（r