甲醛引起小鼠免疫毒性及氧化损伤的研讨.pdf

288 环境污染对健康的影畸一“环境污染与健康”田际研讨会论文集 甲醛引起小鼠免疫毒性及氧化损伤的研究 原福胜 (山西医科大学公共卫生学院环境卫生教研室，太原030001) MDA)含量的影响。【方法隧用健康清洁级昆明种小鼠30只，随机分成5组(印阴性对照组，lmg／m3。3n,lg／m3，5mg／m’染毒组和阳性对照 果】随甲醛染毒剂量的增高，小鼠脾脏，胸腺CD，、CD4，CD8含量呈明显下降趋势，CDJCD8随染毒剂量的升高而明显增大，与阴性对照 甲醛导致免疫损伤的作用机制乏一． 关键词：甲醛CD3CD4CD。氧化损伤 onImmune andOxidative Study Toxicity Damages inMiceInduced byFormaldehyde Yuan Fusheng ofEnvironmental ofPublic Medical 030001) (Dept Health，SchoolHealth，ShanxiUniversity，Taiyuan andtheac：dvldesofSODandthecontentsofMDAin Abstract：【oblective]ToexploretheinfIIIence∞theco,tentsofCD3,CD．，CDespleenandthymus ofmiceInduced KMmicewere dMdedinto5 conuDl byformaldehyde．[methodslThirty randomly groups笛followln零negativegroup，1mg，m3,3 FAInhalationand control were tOFA inalaflonInastatictotal forl mg／m3,5mgdm3 groupspositive group．Miceexposedby enclosurechamber4days． Thecontents dlaldehyde(MDA)andthe andthymusweredetermined． ofCDj,CD．，CD8，malelc acdv咐岱Of如卵删dedbmutase(SoD)，spleen of resultshoweda decline ofcontents of and ofrakewithdoseIncreased．Therewere [resul岱】TtIe significanttendency CD3,CD4,CD8spleenthymus 曲lvI伽s relationbetweenthe significanceInFAInhalationgroup coutentsof of and ofmiceandthedose CD3，CD．，CD8spleenthymus offormaldehydeInhabited．Comparingwith口托control FAInhalation