潘妥拉唑钠注射液治疗消化性溃疡合并上消化道出血多中心临床研究 黄晓宇.docVIP

精品论文 参考文献 潘妥拉唑钠注射液治疗消化性溃疡合并上消化道出血多中心临床研究 黄晓宇 江苏省南京市栖霞区医院 江苏 南京210000 摘要：目的：研究潘妥拉唑钠注射液治疗消化性溃疡合并上消化道出血的临床疗效。方法：回顾分析2014年6月至2015年6月期间在我院消化内科诊治的50例消化性溃疡合并上消化道出血患者临床资料，将其随机分为对照组和研究组，每组25例患者，研究组患者给予潘妥拉唑钠注射液治疗，对照组患者给予奥美拉唑治疗，连续治疗5天，对比两组患者临床治疗效果。结果：研究组患者3天内止血24例，有效率为96%，1例患者于4-5天内止血，临床治疗总有效率为100%，对照组患者3天内止血23例，有效率为92%，2例患者4-5天内止血，临床治疗总有效率为100%，两组对比差异无统计学意义(Pgt;0.05)；两组患者在治疗第2天开始，黑便次数、出血量均明显减少，但两组对比差异无统计学意义(Pgt;0.05)；研究组患者治疗后胃部pH平均升高3.6plusmn;0.5，对照组患者胃部pH值的平均升高2.7plusmn;0.3，两组对比差异具有统计学意义（P＜0.05）。结论：潘妥拉唑是治疗消化性溃疡合并上消化道出血的有效药物，其疗效与奥美拉唑相似，临床无不良反应，值得在临床推广和应用。 关键词：潘妥拉唑钠；消化性溃疡；消化道出血 【中图分类号】R573.1【文献标识码】 A Abstract: objective: to study the torah pan azole sodium injection in the treatment of peptic ulcer with upper gastrointestinal hemorrhage curative effect. Methods: retrospective analysis in June 2014 to June 2015 in our hospital, the hospital make a diagnosis and give treatment of 50 cases of peptic ulcer with upper gastrointestinal bleeding in patients with clinical data, which were randomly divided into control group and research group, each group of 25 patients, the team with pan torah azole sodium injection treatment, control group patients give omeprazole treatment, treatment for five days in a row, compared two groups of patients with clinical therapeutic effect. Results: bleeding within three days of 24 patients with the team, the effective rate was 96%, 1 case of patients from 4 to 5 days to stop bleeding, clinical treatment the total effective rate was 100%, stop bleeding within three days of 23 patients with the control group, the effective rate of 92%, 4-5 days to stop bleeding, 2 cases with clinical treatment the total effective rate was 100%, two groups of contrast differences had no statistical significance (P gt; 0.05); Two groups of patients in the treatment of 2 day, black number, the bleeding were significantly decreased, but difference compared the two groups have no statistical significance (P gt; 0.05); Group after treatment in patients with gastric pH