环孢菌素联合康力隆治疗再生障碍性贫血疗效观察.docVIP

精品论文 参考文献 环孢菌素联合康力隆治疗再生障碍性贫血疗效观察 李宏雨1 黄永生1 杜洪涛1 胥艳红1 武继红1 陈秋霞1 梁梅2 1 鄢陵县中医院（河南 鄢陵461200）2郑州大学第一附属医院 【摘要】目的 观察环孢菌素（CsA）联合康力隆治疗再生障碍性贫血（再障）的疗效和不良反应。方法 共48例再障均采取CsA 4mg/kg/d联合康力隆4-6mg /d治疗，持续用药满6个月时，根据国内制定的疗效标准评估疗效，并观察副作用。结果 48例中基本治愈19（39.6%）例，缓解18（37.5%）例，明显进步4（10.4%）例，无效6（12.5%）例，总有效率87.5%，未发现明显的不良反应。结论 CsA 联合康力隆治疗再障的疗效显著，很值得推荐.我们的资料提示大多数再障患者的发病存在着自身T细胞介导的免疫因素。 【关键词】 贫血 再生障碍性 环孢菌素 康力隆 ［中图分类号］R ［文献标识码］A ［文章编号］1810－5734(2010)12-0004-02 Clinicalobservation of CsA and stanozolol therapy for patients with aplastic a nemia.〖WTBZ〗LiHongyu, Huang Yongsheng, Du Hongtao, Xu Yanhong, Department of hematology, The traditional Chinese hospital of Yanling count,Yanling 461200. 【Abstract】Objective 【WTBZ】 To observe the efficiency and side effect of cyclosporin(CsA) and stanozolol combination in the treatment of aplastic anemia(AA),[WTHZ]Method[WTBZ] Forty eight patients with AA of whom 29 were males 19 females and median age 32.4 years entered into the study. The dose of CsA was 4mg/kg/d,and stanozolol was 4-6mg every day.The efficiency and adverse effects of CsA and stanozolol combin ation were evaluted according to the criteria in the end of sixth months 0f trea tment. Result Forty of 48 patients with AA achieved the hematol ogy improvement and the improveneut rate was 87.5%,no significent side effect was observed. Conclusion The CsA combined with stanozolol is an effective and well-tolerated therapy for AA,Our Clinical data suggest that the T cell mediated immune reaction may be an important factor in the pathegensis of most patients with aplastic anemia. 【key words】 Anemia aplastic Cyclosporine stanozolol 再生障碍性贫血（再障），临床以骨髓造血衰竭， 全细胞减少为特征。研究表明大多数再障患者的发病与自身T细胞介导的免疫有关，应用免疫抑制剂治疗有效。我们采取环孢菌素（CsA）联合康力隆治疗再障48例，取得了良好疗效，现报道于下。 1 病例和方法 1.1 病例 共48例再障，其中男29例，女19例，年龄12-62岁，中位年龄31.5岁，所有病例均经血与髓像检查确诊，符合国内制定的诊断标准［１］，疗前病程4-7个月，中位病程4.2个月。 入院时血像：Hb 35-78g/L,中位数47 g/L,WBC(18-37)times;109 /L,plt(25-74) times;109/L,网织红细胞0.1-0.5%