瑞舒伐他汀钙治疗高血压病患者颈动脉粥样硬化102例的疗效观察.docVIP

精品论文 参考文献 瑞舒伐他汀钙治疗高血压病患者颈动脉粥样硬化102例的疗效观察 （四川省科学城医院 四川 绵阳 621900） 　　【摘要】 目的：探讨瑞舒伐他汀钙治疗高血压病患者颈动脉粥样硬化的临床疗效。方法：102例确诊为高血压病2～3级合并有颈动脉粥样硬化的患者，在常规治疗（包括拜阿司匹林或氯吡格雷，氨氯地平，或氨氯地平+厄贝沙坦等）的基础上加用瑞舒伐他汀钙，治疗组每晚睡前１次10mg，低剂量组每晚睡前１次5mg，疗程为12个月。观察治疗前后血脂、颈动脉内膜中层厚度IMT、斑块积分变化。结果：治疗组减低颈动脉1MT和斑块积分均明显优于低剂量组(P﹤0.05)。血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平显著降低(P均lt;0.05)，高密度脂蛋白胆固醇(HDL-C)显著升高(Plt;0.05)，两组治疗后血脂均明显改善(P﹤0.05)。结论：在常规治疗的基础上加用瑞舒伐他汀钙10mg治疗高血压病人颈动脉粥样硬化疗可以降低血脂水平、颈动脉1MT和斑块积分，副作用少，值得推广应用。 　　【关键词】 高血压病；瑞舒伐他汀钙；颈动脉粥样硬化；动脉彩超；血脂 　　【中图分类号】R544.1 【文献标识码】A 【文章编号】2095-1752（2016）34-0037-02 　　Rui Shu Calcium Cut Statin Treatment Hypertension Patient Curative Effect Observation of 102 Cases of Carotid Atherosclerosis 　　Zeng Yang Jie, Shi xiaoqiong, Wei Mingyong, Wu Jun.Science City Hospital in Sichuan Province, Sichuan Mianyang, 621900,China 　　【Abstract】 Objective To study the calcium rui shu cut statin treatment the clinical curative effect of hypertension patients of carotid atherosclerosis. Methods 102 patients diagnosed with hypertension 2-3 patients with carotid atherosclerosis, in the conventional treatment (including aspirin or clopidogrel, amlodipine, or amlodipine + er bei sha temple, etc.) on the basis of added by a comfortable cut statin calcium, treatment group 1 times 10 mg every night before going to bed, every night before sleeping, 1 5 mg, low dose group therapy for 12 months. Were observed before and after treatment of blood lipids, carotid intima-media thickness IMT, plaque integral change. Results The treatment group reduced 1 mt and carotid plaque score were significantly better than that of low dose group (P ﹤ 0.05). Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL - C) were significantly reduced (P lt; 0.05), high density lipoprotein cholesterol (HDL - C) increased significantly (P lt; 0.05), two groups of blood lipid were significantly improved after treatment (P ﹤ 0.05). Conclusion On the basis of conventional treatment comb