生理盐水冲洗联合玻璃酸钠注射治疗膝骨性关节炎的临床研究.docVIP

精品论文 参考文献 生理盐水冲洗联合玻璃酸钠注射治疗膝骨性关节炎的临床研究 李兴 　　（新疆伊宁市武警8660部队医院 新疆伊宁 835000） 　　【摘要】目的 观察生理盐水冲洗联合玻璃酸钠关节内注射治疗膝骨性关节炎的临床疗效。方法 将130例膝骨性关节炎患者随机分为3组，分别采用关节内生理盐水（NS）冲洗、玻璃酸钠（HA）关节内注射、生理盐水冲洗+玻璃酸钠注射（NS+HA）治疗，临床观察膝关节疼痛、肿胀和功能改善情况，并进行评分，三类评分累加为症状体征积分，以此评价疗效。结果 各组患者治疗后即时症状体征积分均明显降低，并随时间延长，积分呈平缓下降，第8周治疗结束后，各组症状体征积分均较治疗前降低（t=10.020，P=0.003；t=22.110，P=0.001；t=56.190，P=0.000）；3组间症状体征积分差异有统计学意义（F=8.784，P=0.001），组间两两比较，NS组积分高于HA组和NS+HA组（q=3.003，P=0.037；q=4.063，P=0.001），HA组积分高于NS+HA组（q=2.537，P=0.024）。结论 膝关节内生理盐水冲洗后注射玻璃酸钠治疗骨性关节炎效果好、起效快、持续时间长，对快速改善患者症状和缩短疗程、节省治疗费有非常积极的意义。 　　【关键词】 膝骨性关节炎 生理盐水　冲洗 玻璃酸钠注射液 注射 　　【中图分类号】R45 【文献标识码】A 【文章编号】2095-1752（2014）02-0045-02 　　 　　Clinical research on treatment of normal saline flush combined with Intra-articular injection of Hyaluronic acid on knee osteoarthitis　LIxing (8660 hospital of Chinese Armed Police,Yining,Xinjiang,835000,China) 　　【ABSTRACT】 Objective: To observe the clinical curative effect of normal saline flush combined with intra-articular injection of hyaluronicacid knee osteoarthritis.Methods:Randomly divide the patients to 3 groups and treat them with methods of NS, HA and -NS+HA differently and separately, then observe the extension of the situation of joint pain, swelling and improvement of joint function of the knees, a scoring was also taken in the meantime. The accumulation of the above mentioned 3 scoring is referred to as symptomatical score, which is used to evaluate the effects of the afore-mentioned different 3 methods.Result: The on-spot scores of the 3 groupsrsquo;patients after the treatments were all significantly lowered. Meanwhile, the scoring shows a gentle trend of decreasing with the elongation of the time of treatment.When the treatments ends in the 8th week, all scoring of the 3 groups are lower than the ones before the treatments were taken(t=10.020，P=0.003；t=22.110，P=0.001；t=56.190，P=0.000);The differences of the syptomatical accumulated scores between the 3