盐酸硫必利片与利培酮口服液治疗酒精所致精神障碍的对照研究.docVIP

精品论文 参考文献 盐酸硫必利片与利培酮口服液治疗酒精所致精神障碍的对照研究 （成都市锦江区锦欣精神病医院 四川成都 610000） 　　【摘要】目的：比较盐酸硫必利片与利培酮口服液治疗酒精所致精神障碍的疗效及安全性。方法：将符合入组的40例男性酒精所致精神障碍患者随机分入盐酸硫必利片组和利培酮口服液组，进行为期４周的观察治疗。使用阳性与阴性症状量表（PANSS）对药物疗效进行评估，使用TESS量表对药物的安全性进行评估。结果：盐酸硫必利片与利培酮口服液两组疗效差异无显著性。盐酸硫必利片主要不良反应为口干及视物略模糊，利培酮口服液主要不良反应为锥外系反应及体重增加。结论：盐酸硫必利片可以明显改善慢性酒精中毒引起的精神症状，其疗效与利培酮口服液相当，且不良反应少，安全性好。 　　【关键词】盐酸硫必利片；利培酮口服液；酒精所致精神障碍 　　【中图分类号】R749.05 【文献标识码】A 【文章编号】1007-8231（2016）21-0099-02 　　【Abstract】Objective To comparative sulfur will benefit hydrochloride and risperidone oral liquid efficacy and safety for the treatment of mental disorders due to use of alcohol. Methods Would be in into the group of 40 cases of male patients with mental disorders due to use of alcohol as random points into the sulfur will benefit hydrochloride group and risperidone oral liquid group, observed treatment for 4 weeks. Use positive and negative symptoms scale (PANSS) to evaluate drug curative effect, use of TESS scale to evaluate the safety of the drug. Results Sulfur will benefit hydrochloride with risperidone oral liquid in the two groups there was no significant difference effect. Hydrochloric acid sulfur will be the main adverse reactions for dry mouth and slightly blurred vision, risperidone oral liquid main adverse reaction for the extrapyramidal system and weight gain. Conclusion Sulfur will benefit hydrochloride can obviously improve the symptoms of chronic alcoholism caused by mental, the curative effect of risperidone oral solution and its and less adverse reaction, good safety. 　　【Key words】Sulfur will benefit hydrochloride; Risperidone oral solution;Mental disorders due to use of alcohol 　　近年来，酒精所引起的精神障碍的发病率逐年增加[1???2]。盐酸硫必利片在国外已被广泛应用于酒精所致精神障碍的治疗，国内相关的研究较少。有研究显示，利培酮口服液治疗酒精性精神障碍安全、有效[3]。本文以利培酮注射液作对照，使用国产盐酸硫必利片治疗酒精所致精神障碍20例，对其疗效及安全性进行比较，现报告如下。 　　1.对象与方法 　　1.1 研究对象 　　收集我院2014年6月至2015年12月的住院男病人40例，按入院先后奇偶数分为利培酮口服液组和盐酸硫必利组。满足以下条件：（1）符合ICD-10 酒精所致精神障碍（幻觉症或妄想症）的诊断标准。（2）从未使用任何抗精神病药物或停用抗精神病药2周以上。（3）饮酒史ge