盐酸羟考酮复合右美托咪啶用于老年患者ERCP术的可行性研究.docVIP

精品论文 参考文献 盐酸羟考酮复合右美托咪啶用于老年患者ERCP术的可行性研究 张骐 崔雯 　　安徽省芜湖市第二人民医院麻醉科 安徽 芜湖 241000 　　【摘要】目的 探讨盐酸羟考酮注射液复合右美托咪啶用于老年患者ERCP术的可行性。方法 行ERCP术老年患者40例，年龄70～85岁，随机分为盐酸羟考酮右美托咪啶组（Q组）和右美托咪啶组（D组），每组各20例。Q组患者单次静脉注射盐酸羟考酮5mg后持续静脉泵注右美托咪啶0.6ug/Kg，维持采用0.8mg?Kg-1?h-1泵注，术中维持BIS值＜70；D组单次静脉注射生理盐水5ml后持续静脉泵注右美托咪啶0.6ug/Kg，维持采用0.8mg?Kg-1?h-1泵注。分别观察两组患者手术开始时间、手术时间、术毕苏醒时间、清醒时间及右美托咪啶用量；术中呼吸抑制及术后躁动发生率；术后30min、1h、2hVAS评分，最后对两组数据进行统计学分析。结果Q组诱导至BIS值＜70的时间、术毕苏醒时间、清醒时间均较D组短（P＜0.05），手术时间两组无差异（P＞0.05），右美托咪啶用量D组大于Q组（P＜0.05）。两组均未发生呼吸抑制及术后躁动。术后D组VAS评分高于Q组（P＜0.05）。结论 盐酸羟考酮注射液与右美托咪啶配伍用于老年患者ERCP术，呼吸抑制轻微，无术后躁动，血流动力学稳定，苏醒更快更平稳，术后患者更加舒适。 　　【关键词】盐酸羟考酮；ERCP；老年患者 　　[Absract]Objective:To investigate the feasibility of Oxycodone Hydrochloride Injection composite Dexmedetomidine used for elderly patients with ERCP. Methods: Forty patients, the age of 70 ~ 85 years old，under going ERCP were randomly assigned into two groups (n=20). Q group of patients continuous intravenous pumping dexmedetomidine 0.6ug/Kg after a single intravenous oxycodone hydrochloride，maintain with 0.8mg?Kg-1?h-1，Intraoperative maintain the BIS value lt; 70. D group of patients continuous intravenous pumping dexmedetomidine 0.6ug/Kg after a single intravenous NS，maintain with 0.8mg?Kg-1?h-1.Recorded the patientsrsquo; starting time of the surgery;the operation time;awakening time;the total administered dose of dexmedetomidine; intraoperative incidence of respiratory depression and postoperative agitation;VAS after 30min、1h、2h postoperation. Results: Q group induced to BIS valuelt; 70 time shorter than group D，awake time extended D than Q group，the operation time two groups have no difference，dexmedetomidine dosage group D is greater than Q group. In the two groups were not happened respiratory depression and postoperative agitation. Group D postoperative VAS score higher than the Q group. Conclusion: Oxycodone Hydrochloride Injection composite Dexmedetomidine used for elderly patients with ERCP, respiratory depression mild, no postoperative agitation,