出血热肾综合征PPT.ppt

Hemorrhagic Fever with Renal Syndrome;■ Definition ▲ Infectious diseases with natural source ▲ Pathogen: Hantan virus ▲ Characterized by fever, hemorrhage, proteinuria, shock and acute renal failure. Five phases in the typical cases ; Epidemic Hemorrhagic Fever ( EHF) Suggested name by WHO in 1982: Hemorrhagic Fever with Renal Syndrome (HFRS);Hantan virus ▲ Member of the family of Bunyaviridae ▲ Feature of virus Single-strand negative RNA virus Circular or oval in shape 78~210 nm in diameter Envelope proteins:glycoprotein1(G1) glycoprotein2(G2) Viral genome—RNA: L M S gene ; Viral proteins L--- Polymerase M---Envelope protein G1 and G2 the membrane antigen G2: contain neutrolization antigen (vaccine antigen) S---Nucleocapsid protein: strong antigenicity and immunogenicity, and containing complement binding antigen. ; ▲ Resistance of virus Low resistance: Inactivated by acid (pH 5.0), ethanol, ether, chloroform. heat in 56oC for 30min or 100oC for 1min. Be sensitive to alcohol ultraviolet rays;■ Epidemiology 1.Sources of infection ? In our country: Apodemus agrarius (黑线姬鼠) Mus norvegicus (褐家鼠) Apodemus sylvaticus (大林姬鼠) Citellus undulatus (长尾黄鼠) ? Laboratory Rats ? Other animals: cats dogs rabbits Patients:unimportant;Apodemus agrarius 黑线姬鼠;2. Modes of transmission: Five 1.Air-borne transmission via inhale aerosol contaminated with virus- containing excretion or secretion of rats 2.Food-borne transmission via oral and esophageal mucosa (eat food contaminated with virus-containing excretion or secretion of rats); 3. Infection via contact Be bitten by rats. wound is contaminated with virus-containing excretions or secretions of rats