恶性黑色素瘤药物发展PPT.ppt

* * * * * * * * * * * * * * * * Cancer cells acquire certain characteristics that affect regulatory circuits governing normal cell proliferation and homeostasis. Normal cells require mitogenic growth signals before they can progress from a quiescent state into proliferation, and antiproliferative signals operate to maintain tissue homeostasis (Hanahan Weinberg, 2000). Cancer cells can acquire capabilities that allow them to grow unchecked in the absence of growth-stimulating signals while overcoming growth-inhibitory signals and host immune responses. Tumor cells may possess any of the follo