舍尼亭联合坦索罗辛治疗女性膀胱过度活动症的疗效观察.docVIP

精品论文 参考文献 舍尼亭联合坦索罗辛治疗女性膀胱过度活动症的疗效观察 辛宇鹏(通讯作者) 任碧华 （四川省绵阳市中心医院泌尿外科 621000） 【摘要】目的 探讨舍尼亭联合坦索罗辛治疗女性膀胱过度活动症的疗效。方法 采用随机分组法将60例患者随机分为两组各30例,联合用药组口服托特罗定2mg/次(Bid) + 坦索罗辛0. 2 mg/次(Qn)，对照组口服托特罗定2mg/次(Bid), 持续8周。以自由尿流率的主要参数如最大尿流率(Qmax) 、平均尿流率(Qave) 、排尿量(VV) 和尿道综合征症状评分(FUSS) 、生活质量评分(QOL)为主要疗效指标,来观察治疗效果。结果 服药8周后，两组尿流率参数值(Qmax、Qave、VV)均较治疗前有改善，尿道综合征症状评分(female urethral syndrome score , FUSS)显著下降，治疗后联合用药组和对照组的尿流率参数值(Qmax、Qave、VV)、FUSS、QOL 相比较,差异显著(Plt;0.05)。结论 舍尼亭加联合坦索罗辛应用可改善逼尿肌不稳定患者的下尿路症状和生活质量,可作为女性膀胱过度活动症的一种有效治疗手段。 【关键词】女性膀胱过度活动症 尿流率 舍尼亭 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2013）14-0161-02 Investigating the Effect of Tolterodine combined with Tamsulosin in Treatment of of female overactive Bladder Xin Yu-peng, Ren bi-hua (Department of Urology, Mian yang central Hospital Mian yang 621000,) 【ABSTRACT】 Objective 　To evaluate tolterodine tartrate and tamsulosin in the treatment of patients with female overactive bladder (OAB) . Methods The patients were randomized into 2 groups. The study group was given tolterodine 2mg twice/d plus tamsulosin 0. 2mg/d, and the control group was given tolterodine 2mg twice/d. 60 female patients suffering from overactive bladder were treated with tolterodine tartrate and tamsulosin tablet for 8 weeks . The effects were evaluated mainly with urodynamic data , including maximum f low rate (Qmax), average flow rate (Qave) , voiding volume (VV) , female urethral syndrome score ( FUSS) and quality of life (QOL) . Results 　In study and control groups, urodynamic data (Qmax , Qave ,VV) increased , while FUSS decreased significantly after 8 weeks treatment . There was statistically significant difference in study and control groups of urodynamics data , FUSS and QOL after treatment (P lt; 0. 05) . Conclusion 　Tolterodine tartrate and tamsulosin can improve LUTS and QOL for patients of BOO with quality of life and could be an effective themrapeutic method for patients wit h OAB. 【KEY WORDS】 f