D-二聚体在肺栓塞中的应用-英文课件PPT.ppt

D-dimer in Pulmonary embolism The 1st Hospital Of Jilin University Zhenggiu Wang Outline Part I Formation of D-dimer Part III D-dimer and Clinical Probability in Suspected PE D-dimer and Clinical Probability in Suspected PE Acute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376. Arch Intern Med.2004;164:2483-2487 ※ D-dimer and Clinical Probability in Suspected PE ※The cut-off of D-dimer in VTE Arch Intern Med.2004;164:2483-2487 D-dimer and Clinical Probability in Suspected PE Part IV D-dimer and anticoagulation ※ D-dimer concentration and anticoagulant therapy NEJM2006;355;1780-9; D-dimer Testing to Determine the Duration of Anticoagulation Therapy 曲线1 曲线2 曲线3 Part IV D-dimer and anticoagulation Baseline characteristics：年纪更大、并发症更多、随访时间更长 Part IV D-dimer and anticoagulation Figure 3. Cumulative incidence and hazard ratios(HRs) of main outcomes according to D-d time course from the third month (T90) to the 13th month (T390). Group 1: Patients in whom D-d was normal at T90 and afterward (with D-d becoming abnormal only once). Group 2: Patients in whom D-d became abnormal at T90 and afterward remained altered persistently or at least twice. Group 3: Patients in whom D-d became abnormal after T90 and afterward remained abnormal persistently or at least twice. NEJM,356;4;January 2007; D-dimer and anticoagulation ※The cut-off of D-dimer in VTE ※ D-dimer and recurrent VTE Part II D-dimer and Age ※ D-dimer and recurrent VTE ※D-dimer and recurrent VTE Part V D-dimer cut-off and Age D-dimer in Pulmonary embolism The 1st Hospital Of Jilin University Acute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376. Acute Pulmonary Embolism；Curr Probl Cardiol 2010;35:314-376. Fatal PE according to Age Figure 1:Distribution of D-dimer results for age groups (a)40years, (b)40-60years(c)60-80years,and(d)80years.A D-dimer result is reported as negative if below 500ng