aBioinformaticsbasicsA生物信息学基础课件.pptxVIP

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2018-01-22 发布于广东
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aBioinformaticsbasicsA生物信息学基础课件.pptx

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生物信息学Bioinformatics;About me;课程提纲;Outline;What is bioinformatics?;;What is bioinformatics?;Solid knowledge of mathematics and statistics Professional skill of computing Deep understanding of life sciences i.e. Data mining algorithms Bioinformatics servers and tools Cancer genome research ;Central Dogma of Biology（中心法则）;Central Dogma for Biologists;Central Dogma for bioinformaticians;Goal of this course;Pre-requisite;Why learn bioinformatics? ;Why teach bioinformatics? ;2018/1/20 Saturday;生物信息学的未来;18;;精准医疗（Precision Medicine）;NIH主任Collins：精准医疗的第一步是数据有效整合;Course Outline;课程提纲;Assessment;参考书;参考书;参考书;参考书;Outline;The foundations;The foundations;The foundations;STAT115;STAT115;The human genome project (HGP);Milestones of Human Genome Project;Main goals of HGP;Human Genome;April, 1953;2000.6.26. East Room of White House;About Dr. Francis S. Collins;“It’s a happy day for the world. It is humbling (令人羞辱的) for me, and awe-inspiring (令人惊叹的), to realize that we have caught the first glimpse of our own instruction book, previously known only by God.” -- Francis Collins ;If 1000 letters per page, 1000 pages per book, we need 2800 books to record the human genome.;44;Fully sequenced, draft genomes;46;What do we share?;Post Genomics Era (03-07);The foundations;Sequencing in 2007;Genomics Era Re-Started;Sequencing 2013;Sequencing in 2014;Sequencing in 2015;在基因测序领域，谁控制仪器，谁就会赢得天下;Only several hours ;Cost per sequencing a human genome;Outline;Personal genome era;Genome gets personal;Personal Omics;Highlights Human genome 13 years 2.4 billions Venter genome 2 years 100 million Watson genome two months 1 million dollars Many two months 1 million dollars ;1,000 Genome Project;1,000 Genome Project;大规模基因组测序计划;Outline;Personal Genomics ? Personal Health Care;Antonarakis et al, 2014. NEJM;Personalized Medicine (个性化医疗）;New industry Personalized Health Care (个性化医疗保健）;Outline;Big Data Challenges;Biological Data;The explosion in biological data !;79;;0.2 TB (2008) ? 71 TB (71,000 GB) (Nov