临床药物手册( 英文原版)7.pdfVIP

Hematologic Drugs Coagulants and Anticoagulants ABCIXIMAB ReoPro Pharmacology. Abciximab is a chimeric human-murine monoclonal antibody Fab fragment that binds to and irreversibly inhibits the platelet glycoprotein IIb/IIIa receptor. Blockade of the glycoprotein IIb/IIIa receptor prevents fibrino- gen from binding, thereby inhibiting platelet aggregation. Abciximab also binds to the vitronectin receptor