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临床药物手册( 英文原版)7
Hematologic Drugs
Coagulants and Anticoagulants
ABCIXIMAB ReoPro
Pharmacology. Abciximab is a chimeric human-murine monoclonal antibody
Fab fragment that binds to and irreversibly inhibits the platelet glycoprotein
IIb/IIIa receptor. Blockade of the glycoprotein IIb/IIIa receptor prevents fibrino-
gen from binding, thereby inhibiting platelet aggregation. Abciximab also binds to
the vitronectin receptor found on platelets, endothelial cells, monocytes, and
smooth muscle cells; the clinical relevance of this is unknown. Abciximab inhibits
platelet aggregation and prolongs bleeding time in a dose-dependent manner.1,2
Administration and Adult Dosage. IV for percutaneous coronary intervention
0.25 mg/kg as a bolus 10–60 min before starting percutaneous coronary interven-
tion and then 0.125 µg/kg/min (up to 10 µg/min) by continuous infusion for 12 hr.
IV for unstable angina and planned percutaneous intervention within 24 hr
0.25 mg/kg as a bolus and then 0.125 µg/kg/min (up to 10 µg/min) by continuous
infusion for 18–24 hr, concluding 1 hr after the percutaneous coronary interven-
tion. (See Parameters to Monitor and Notes.)
Special Populations. Geriatric Dosage. Same as adult dosage.
Dosage Forms. Inj 2 mg/mL.
Pharmacokinetics. Onset and Duration. Rapid inhibition of platelet function after
IV administration. Platelet function gradually recovers after discontinuation of the
IV infusion; bleeding time approaches baseline values within 24 hr and ex vivo
platelet aggregation approaches baseline levels within 48 hr. Low levels of glyco-
protein IIb/IIIa inhibition are detectable for up to 14 days after administration.1
Fate. Abciximab is rapidly cleared from the plasma after administration by rapid
binding to the glycoprotein IIb/IIIa recept
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