败血症新生儿凝血功能临床检测.docVIP

精品论文 参考文献 败血症新生儿凝血功能临床检测 （苏州大学附属儿童医院 江苏 苏州 215003） 　　【摘要】目的：探讨败血症新生儿凝血功能的变化及其临床意义。方法：将足月新生儿分为败血症组及对照组；败血症患儿符合新生儿败血症诊疗方案；无影响凝血功能因素的新生儿为对照组。收集入院时及3～7d间凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)、凝血酶时间(TT)、AT-Ⅲ活性、维蛋白原(FIB)、D-二聚体(DD)含量和血小板(PLT)计数等7项检查指标变化。结果： 在入院早期，与对照组新生儿相比，败血症新生儿APTT、PT明显延长，PLT计数减少，差异有统计学意义；随着病程进展，部分败血症患儿出现DIC状态，其早期凝血指标与未发展至DIC状态的患儿早期凝血指标相比，只有DD存在差异，其余指标差异无统计学意义；败血症患儿DIC时期较其早期非DIC期凝血指标相比，AT-Ⅲ活性、PLT计数明显降低、DD含量增高，差异有统计学意义。结论：新生儿在败血症病理过程中出现凝血功能紊乱，且随疾病进展出现动态变化，临床及时检测凝血功能，及早对症处理，预防DIC，减少死亡率。 　　【关键词】新生儿；败血症；凝血功能紊乱 　　【中图分类号】R722.13+1 【文献标识码】A 【文章编号】2095-1752（2016）28-0194-03 　　Clinic Analysis of Coagulation Function of Neonatal Sepsis 　　Gao Shasha.Childrenrsquo;s Hospital Affiliated to Soochow University,Suzhou 215003,China 　　【Abstract】Objective To explore the change of coagulation function and its clinical significance in neonates with sepsis in NICU.Methods In the retrospective study,the full-term neonates were divided into two groups,septic groups and control group.The diagnosis of sepsis accorded with Protocol for diagnosis and treatment of neonatal septicemia,and the control group had no factors effect coagulation function. In the meantime,their prothrombin time(PT),thrombin time(TT),activated partial thromboplastic time(APTT),AT-Ⅲactivity,fibrinogen(FIB),DD level and platelet counts(PLT) were determined in first day and between third and seventh days in hospital.Results In the early phase of disease,between control neonates group and septic neonates group,APTT,PT were higher in the study group than the control group,PLT was significantly lower in the study group than the control group,and the diffrence had statistical mean.As the disease progresses,some patients appeared DIC;Compared with these septic neonates who did not appeared DIC,only D-D of the former was significantly higher in their early phase of disease,the rest diffrence had nostatistical mean.Compared with their early stages without DIC,some patients in the period of DI