超纯透析对维持性血液透析患者贫血及氧化应激反应的影响.docVIP

精品论文 参考文献 超纯透析对维持性血液透析患者贫血及氧化应激反应的影响 李佳　张以来　魏善斋　冯占荣　孙杰　朱海峰 江苏省沭阳县中医院肾内科　江苏　沭阳　２２３６００ 作者简介:李佳,女,(１９７９．１２),研究生,硕士,副主任医师,肾脏病的诊治和血液净化治疗江苏省宿迁市科技指导性课题 　　【摘要】　目的　研究超纯透析对维持性血液透析(Maintenancehemodialysis,MHD)患者贫血及氧化应激反应(OSR)的影响.方法　选取我院２０１３年１１ 月至２０１４年１１月期间收治的接受MHD治疗患者１０２例,作为本次研究对象.根据数字法随机将其分为观察组和对照组,对照组患者接受普通透析方式治疗,观察组实施超纯透析.对比两组患者治疗前后贫血情况,两组患者治疗前后OSR 相关指标变化情况,以及两组不良反应情况.结果　治疗后两组的Hb及HCT水平均上升,beta;２－MG水平均下降,但观察组的的Hb及HCT水平显著高于对照组,而beta;２－MG水平显著低于对照组,差异均有统计学意义(均P＜０．０５).治疗后观察组的Alb水平显著高于对照组,MPO、CRP及MDA 水平均分别显著低于对照组,差异均有统计学意义(均P＜０．０５).观察组的总不良反应率为７．８４％,与对照组的５．８８％相比,差异无统计学意义(P＞０．０５).结论:超纯透析对于MHD患者的贫血及氧化应激状态具有较好的改善作用,效果明显,值得在临床上推广应用. 【关键词】　超纯透析;　维持性血液透析;　贫血;　氧化应激反应;　影响Influenceofultrapuredialysisonmaintenancehemodialysispatientswithanemiaandoxidativestressreaction【Abstract】　Objective:Tostudyinfluenceofultrapuredialysisonmaintenancehemodialysispatientswithanemiaandoxidativestressreaction．Methods:１０２casesofpatientstreatedinourhospitalfromNovember２０１３toNovember２０１４byMHDastheresearchobject．Accordingtodigitalmethodrandomlydividedintoobservationgroupandcontrolgroup,Thecontrolgrouppatientsweretreatedwithregulardialysismode,theobservationgroupimplementationofultrapuredialysis,comparedthetwogroupsofpatientsbeforeandaftertreatmentofanemia,thechangesofOSRindexbeforeandaftertreatmentintwogroups,andtheadversereactionsofthetwogroups．Results:HbandHCTlevelsinthetwogroupswereincreasedaftertreatment,beta;２－MGleveldecreased,butHbandHCTlevelsoftheobservationgroupwassignificantlyhigherthanthatincontrolgroup,whilethelevelofbeta;２－MGwassignificantlylowerthanthecontrolgroup,thedifferenceswerestatisticallysignificant(allP＜０．０５)．TheAlbleveloftheobservationgroupaftertreatmentwassignificantlyhigherthanthatincontrolgroup,MPO,CRPandMDAlevelsweresignificantlylowerthanthoseinthecontrolgroup,thedifferenceswerestatisticallysignificant(allP＜０．０５)．Thetotaladversereactionratewas７．８４％intheobservationgroup,comparedwiththecontrolgroup５．８８％,thedifferencewasnotstatisticallysignificant(P＞０．０５)．Conclusion:Theultrapuredialysisc