转移性结直肠癌的综合治疗.docVIP

精品论文 参考文献 转移性结直肠癌的综合治疗 中山大学附属第五医院 普外科 519000 【摘 要】目的：探讨中山大学附属第五医院的基于分层个体化治疗策略的转移性结直肠癌综合治疗模式的运行效果。方法：回顾性分析从2009年3月至2014年3月，在中山大学附属第五医院住院治疗患有转移性结直肠癌患者的病历资料，比较综合治疗组与非综合治疗组的疗效。结果：综合治疗组与非综合治疗组在住院总时间上没有明显差异（Pgt;0.05），但在围手术期住院时间和外科住院时间上综合治疗组明显少于非综合治疗组（Plt;0.05）；手术治疗效果方面，综合治疗组肿瘤手术有效率明显高于非综合治疗组（Plt;0.05）；术后早期并发症的发生方面，综合治疗组术后早期肠梗阻发生率显著低于非综合治疗组（Plt;0.05），而在吻合口漏和吻合口出血发生率方面，两组间则无统计学差异（Pgt;0.05）。综合治疗组不良反应发生率显著低于非综合治疗组（Plt;0.05）。经过5-10个月的随访后，综合治疗组的患者术后肿瘤复发率显著低于非综合治疗组（Plt;0.05），综合治疗组的患者术后生存时间显著高于非综合治疗组（Plt;0.05），而术后吻合口狭窄和肠梗阻的发生率，两组间没有明显统计学差异（Pgt;0.05）。结论：基于分层个体化治疗策略的综合治疗模式对转移性结直肠癌的治疗，不仅有利于治疗方案中各科时间的合理分配，而且提高了治疗效果，显著地减少了术后早期并发症的发生，降低肿瘤复发率。 【关键词】转移性结直肠癌；个体化治疗；综合治疗；新辅助治疗 【Abstract】Objective：To discuss the performance of combined-therapy of colorectal cancer based on individuation within the fifth affiliated hospital，Sun Yat-sen University. Methods：To compare the therapeutic effect between combined-therapy and non-combined-therapy group by retrospectively analyzing the data of patients who diagnosed colorectal cancer and accepted in-hospital therapy from March 2012 and March 2015. Results：There was no significant difference between combined-therapy and non-combined-therapy group about the total hospitalization time，but the in-hospital days of the combined-therapy group during the perioperative period and in the surgical ward were less than that of the non-combined-therapy group（Plt;0.05）. And the combined-therapy group had a higher rate of overall response rate（Plt;0.05）. Although the incidence of anastomotic leakage and bleeding as early postoperative complications showed no variations between the two groups，the non-combined-therapy group encountered more early postoperative ileus（Plt;0.05）. There was significant difference in the side effects between two groups（Plt;0.05）. During the 5-10 months follow-up，there came out less cancer recurrence rate and longer median survival time（MST）in the combined treatment group than the other（Plt;0.05）. And the morbidity of anastomotic strict