不同针灸方法治疗化疗所致恶心呕吐临床研究.docVIP

不同针灸方法治疗化疗所致恶心呕吐临床研究 　　摘要：目的 ?^察不同针灸方法治疗化疗所致恶心呕吐的疗效。方法 163例患者随机分为电针组、温针灸加电针组、隔姜灸组和对照组4组，分别为42、37、44、40例。各组均行术后辅助联合化疗。3个针灸组分别于化疗前1 d采用电针、温针灸加电针、隔姜灸刺激双侧足三里、内关，每日1次；对照组予盐酸托烷司琼5 mg+生理盐水100 mL，于化疗前30 min静脉点滴，每日1次至化疗结束。观察呕吐次数和程度，检测血清5-羟色胺（5-HT）含量，并进行安全性监测。结果 电针组、温针灸加电针组急性呕吐完全控制率及有效控制率均高于隔姜灸组和对照组（P 　　关键词：电针；温针灸；隔姜灸；化疗呕吐 　　DOI：10.3969/j.issn.1005-5304.2017.03.009 　　中图分类号：R246.1 文献标识码：A 文章编号：1005-5304（2017）03-0034-04 　　Clinical Study on Different Acupuncture and Moxibustion Methods for Prevention and Treatment of Nausea and Vomiting Caused by Chemotherapy PU Zhong-jian， MA Xiao-ping， WANG Ya-jun， SUN Yuan-peng （Traditional Chinese Medicine Hospital of Haian County， Haian 226600， China） 　　Abstract： Objective To observe efficacy of different acupuncture and moxibustion methods for treatment of nausea and vomiting caused by chemotherapy. Methods One hundred and sixty-three cases were randomly divided into electroacupuncture group （42 cases）， warm acupuncture combined with electroacupuncture group （37 cases）， ginger moxibustion group （44 cases） and control group （40 cases）. All groups received postoperative adjuvant chemotherapy. Three acupuncture and moxibustion groups received electroacupuncture， warm acupuncture combined with electroacupuncture， ginger moxibustion to stimulate bilateral Zusanli （ST36）， Neiguan （PC6）， respectively， once a day. The control group was given tropisetron hydrochloride 5 mg+normal saline 100 mL， 30 min before chemotherapy intravenously， once a day to the end of chemotherapy. The number and degree of vomiting and the serum 5-HT content were tested， and the safety test was conducted. Results The complete control rate and effective control rate of acute vomiting of electroacupuncture group and warm acupuncture combined with electroacupuncture group were higher than those of ginger moxibustion group and control group （P 　　通讯作者：孙元鹏，E-mail：syp681@ 　　control groups， with statistical significance （P0.05），具有可比性，见表1。本研究经本院伦理委员会审核批准。 　　1.2 分组方法 　　采用S