阿立哌唑合并氯氮平治疗难治性精神分裂症对照研究.docVIP

精品论文 参考文献 阿立哌唑合并氯氮平治疗难治性精神分裂症对照研究 尹永珍 　　（云南省精神病医院 云南昆明 650224） 　　【摘要】目的：探讨阿立哌唑合并氯氮平治疗难治性精神分裂症的临床疗效及安全性。方法：将68例难治性精神分裂症患者随机分为两组,组34例, 研究组口服阿立哌唑联合氯氮平治疗, 对照组单用氯氮平治疗, 观察8周, 于治疗前及治疗第2周, 第4周，第8周末采用阳性与阴性症状量表及副反应量表评定临床疗效和不良反应。结果：两组治疗2周末起阳性与阴性症状量表评分均较治疗前有显著下（P＜0.05），研究同期两组间比较均无显著性差异（P＞0.05）, 治疗8周末研究组有效率为63.48%，对照组为51.73%，两组无显著性差异（P＞0.05），研究组不良反应发生率为31.23%，对照组为57.27%，研究组显著低于对照组（P＜0.05）, 研究组主要表现为静坐不能、震颤、体重增加。 对照组主要为流涎、心电图异常、肝功能异常、白细胞减少、嗜睡、头昏、体重增加等。结论：阿立哌唑联合氯氮平治疗难治性精神分裂症疗效显著, 安全性高, 依从性好。 　　【关键词】难治性精神分裂症；阿立哌唑；氯氮平；阳性与阴性症状量表；副反应量表。 　　【中图分类号】R453 【文献标识码】A 【文章编号】1007-8231（2015）20-0050-02 　　Aripiprazole combined with clozapine in the treatment of refractory schizophrenia. 　　【Abstract】Objective The clinical efficacy and safety of aripiprazole combined with clozapine in the treatment of refractory schizophrenia. Methods 68 patients with refractory schizophrenia were randomly divided into two groups, each group have 34 cases,the study group use aripiprazole combined with clozapine to treatment, the control group used clozapine treatment, observe 8 weeks, before treatment and second weeks, fourth weeks and eighth weeks using the positive and negative symptoms scale and side effects scale to evaluated the clinical efficacy and adverse reactions. Results The positive and negative symptom scale scores of the two groups after 2 weeks treatment were significantly lower (P lt; 0.05), the period between the two groups showed no significant difference (P gt; 0.05), after 8 weeks the studygroup effective rate was 63.48%, the control group is 51.73%, the two groups was not statistically significant difference (P gt; 0.05), the incidence of adverse reactions was 31.23% in the study, 57.27% in the control group, the study group was significantly lower than the control group (P lt; 0.05), the study group mainly manifested as akathisia, tremor, weight increased. The control group was mainly salivation, ECG abnormalities, abnormal liver function, leukopenia, le