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amines, including triethylamine, procaine, dibenzylamine, N英文资料.pdf

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United States Patent O C6 3,316,243 Patented Apr. 25, 1967 1 2 3,316,248 easily hydrolyzed esters which are converted to the free SYNTHETIC PENICILLINS acid form by chemical or enzymatic hydrolysis. Lee C. Cheney, Fayetteville, N. ., assignor, by mesne The products of the present invention are prepared by assignments, to Beecham Research Laboratories Ltd., reaction of 6-aminopenicillanic acid, preferably in the Brentford, Middlesex, England, a corporation of Great form of a neutral salt such as the sodium salt or the Britain and Northern Ireland No Drawing. Filed May 25, 1959, Ser. No. 815,287 triethylamine salt, with an acid chloride having the for mula 9 Claims. (Cl. Mil-239.1) This invention relates value as antibacterial agents, ‘ feeds, as agents for the treatment of mastitis in cattle and as therapeutic agents in poultry and an imals, including man, in the treament especially of in wherein R1, R2, R3 and R4 have the meaning set forth fectious diseases caused by Gram-positive bacteria and, 15 above, or its functional equivalent as an acylating agent more particularly, relates to substituted 6-(2-phenoxy