幽门螺杆菌ppt课件.pptVIP

Helicobacter Helicobacter pylori(HP)----gastritis peptic ulcer gastric carcinoma 幽门螺杆菌 与慢性胃炎、消化道溃疡 胃癌 1982年前 辛辣食物 胃酸过多 引起胃溃疡 生活压力 生活方式 目前认为胃溃疡与细菌感染有关 是胃溃疡发病机理的重大发展 与HP感染有关的疾病 Important Properties Similar to campylobacter Strongly urease-positive Flagellar characteristic 重要特性 “S”形，G- 尿素酶阳性 有鞭毛 Pathogenesis TRANSMISSION Person-to-person CLINICAL FINDINGS Recurrent pain in the upper abdomen 上腹部的反复疼痛 Bleeding into the gastrointestinal tract 胃肠道出血 No bacteremia 没有菌血症 Laboratory diagnosis Smears of biopsy sepcimens of the gastric mucosa To be cultured（ gold standard） IgG “urease breath” test:radiolabeled urea is ingested radiolabeled co2 实验室诊断 胃粘膜涂片 培养（金指标） IgG 尿素酶呼吸检测 TREATMENT Antibiotics are the new cure for ulcers; therapy consists of one to two weeks of one or two antibiotics and a medicine that will reduce the acid in the stomach. Amoxycillin（羟氨苄青霉素）, tetracycline(四环素）, metronidazole（灭滴灵） * * It is remarkable that a bacterium that colonizes roughly one-half of the world’s population remained undiscovered until 1983 Barry Marshall HP的发现 1983 Ammonia(neutralizes stomach acid) Inflammation Damage to the mucosa粘膜 Gastritis ，peptic ulcer Organism HP细菌 mucus-secreting cells *