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Cell Cycle 9:22, 4437-4449; November 15, 2010; © 2010 Landes Bioscience
To polyadenylate or to deadenylate
That is the question
1 2 1,
Xiaokan Zhang, Anders Virtanen and Frida E. Kleiman *
1Chemistry Department; Hunter College; City University of New York; New York, NY USA; 2Department of Cell and Molecular Biology; Uppsala University;
Uppsala, Sweden
essenger RNA polyadenylation Introduction
Mand deadenylation are important
Key words: polyadenylation, deadenylation, processes that allow rapid regulation The production of mature mRNA
3 end processing, mRNA steady state lev- of gene expression in response to dif- requires the synthesis of a pre-mRNA by
els, mRNA surveillance, cell differentiation ferent cellular conditions. Almost all RNA polymerase II (RNAP II) and co-
processes, DNA damage, exosome, AU-rich eukaryotic mRNA precursors undergo transcriptional processing of the nascent
element, miRNA a co-transcriptional cleavage followed precursor by 5 end capping, splicing
Abbreviations: RNAP II, RNA polymerase by polyadenylation at the 3 end. After and 3 end processing.1 The 3 end of the
II; CPSF, cleavage-polyadenylation specificity the signals are selected, polyadenylation mRNA is processed by the cleavage of the
factor; CstF, cleavage stimulation factor; PAP, occurs to full extent, sugg
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