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Downloaded from on October 22, 2010 - Published by Cold Spring Harbor Laboratory Press
Human ESC-derived Neural Rosettes and Neural Stem Cell
Progression
Y. Elkabetz and L. Studer
Cold Spring Harb Symp Quant Biol 2008 73: 377-387 originally published online February 9, 2009
Access the most recent version at doi: 10.1101/sqb.2008.73.052
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Copyright © 2008, Cold Spring Harbor Laboratory Press
Downloaded from on October 22, 2010 - Published by Cold Spring Harbor Laboratory Press
Human ESC-derived Neural Rosettes and
Neural Stem Cell Progression
Y. ELKABETZ AND L. STUDER
Developmental Biology Program, Division of Neurosurgery,
Memorial Sloan-Kettering Cancer Center, New York, New York 10065
Neural stem cells (NSCs) are defined by their ability to self-renew while retaining differentiation potential toward the three
main central nervous system (CNS) lineages: neurons, astrocytes, and oligodendrocytes. A less appreciated fact about isolated
NSCs is their narrow repertoire for generating specific neuron types, which are generally limited to a few region-specific sub-
types such as GABAergic and glutamatergic neurons. Recent studies
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