An objective method for regularization of fiber orientation distributions derived from diffusion weighted MRI英文文献.pdfVIP

/locate/ynimg NeuroImage 34 (2007) 169 – 176 Technical Note An objective method for regularization of fiber orientation distributions derived from diffusion-weighted MRI Ken E. Sakaie⁎ and Mark J. Lowe Department of Radiology, The Cleveland Clinic, 9500 Euclid Avenue, Mailcode U-15, Cleveland, OH 44195, USA Received 29 June 2006; revised 30 August 2006; accepted 31 August 2006 Available online 9 October 2006 Spherical deconvolution is an elegant method by which the orientation al., 2004) are a conceptually straightforward extension of the tensor of crossing fibers in the brain can be estimated from a diffusion- model, but can be unstable for cases with more than two fibers weighted MRI measurement. However, higher resolution of fiber (Tuch et al., 2002). directions comes at the cost of higher susceptibility to noise. In this A number of model-independent approaches can describe study, we describe the use of linear regularization of the fiber diffusion in complex tissue. Diffusion spectrum imaging (Wedeen orientation distribution function by Damped Singular Value Decom- et al., 2005) can directly measure the water displacement position. Furthermore, the degree of regularization is optimized on a probability distribution function (PDF) for all directions and voxel-by-voxel basis with no user interaction using Generalized Cross displacement magnitudes, but is limited by prohibitively long scan Validation. We