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Bioengineering Challenges for
Heart Valve Tissue Engineering
Michael S. Sacks, 1 Frederick J. Schoen,2
and John E. Mayer, Jr.3
1Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh,
Pennsylvania 15219; email: msacks@
2 Departments of Pathology, Brigham and Women’s Hospital and Harvard Medical School,
Boston, Massachusetts 02115
3Department of Cardiac Surgery, Children’s Hospital of Boston and Harvard Medical School,
Boston, Massachusetts 02115
Annu. Rev. Biomed. Eng. 2009. 11:289–313 Key Words
First published online as a Review in Advance on heart valves, tissue engineering, functional biomechanics, stem cells,
May 4, 2009
scaffolds, cardiovascular function
The Annual Review of Biomedical Engineering is
online at Abstract
This article’s doi: Surgical replacement of diseased heart valves by mechanical and tissue valve
10.1146/annurev-bioeng-061008-124903
substitutes is now commonplace and enhances survival and quality of life
c
Copyright 2009 by Annual Reviews. for many patients. However, repairs of congenital deformities require very
All rights reserved
small valve sizes not commercially available. Furth
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