原创力文档Contemporary Clinical Research of Traditional Chinese Medicines for Chronic Hepatitis B in China An Analytical Review英文文献.pdfVIP
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Contemporary Clinical Research of Traditional Chinese
Medicines for Chronic Hepatitis B in China: An
Analytical Review
1 1,2 1 3 1 1,4,5,6
Lingyi Zhang, Guqi Wang, Weihong Hou, Ping Li, Andrea Dulin, and Herbert L. Bonkovsky
Chronic hepatitis B (CHB) is major global health problem. In China, where about
120,000,000 persons are chronically infected, CHB has been treated for centuries with
traditional Chinese medicines (TCMs). This review summarizes and meta-analyzes the re-
sults of randomized controlled trials (RCTs) of TCM formulations reported in China in
1998-2008 for treatment of CHB. RCTs comparing either TCM formulations alone or in
combination with interferon (IFN) or lamivudine (LAM) versus IFN or LAM were included.
Chinese electronic databases were searched. The methodological quality of RCTs was as-
sessed using the Jadad scale. TCMs had a greater beneficial effect (P 0.0003) than IFN and
a slightly better effect (P 0.01) than LAM on the normalization of serum alanine amino-
transferase. TCMs had a similar beneficial effect when compared with IFN or LAM for CHB
on antiviral activity as evidenced by the loss of serum hepatitis B e antigen and hepatitis B
virus (HBV) DNA. TCMs enhanced IFN and LAM antiviral activities and improvements of
liver function. The quality of many studies was poor; reports often lacked information
regarding methods of randomization or blinding and adverse events. Conclusion: Some
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