COMMUNICATIONS 0.3 Second FLASH MRI of the Human Heart英文文献.pdfVIP

MAGNETIC RESONANCE IN MEDICINE13,150-1 57 ( 1990) COMMUNICATIONS 0.3-Second FLASH MRI of the Human Heart J. FRAHM,K. D. MERBOLDT,H. BRUHN,M. L. GYNGELL, W. HANICKE,AND D. CHIEN MaxPlanck-Institutfur biophysikalische Chemie,Postfach 2841, 0-3400 Gottingen,Federal Republic of Germany Received June 26, 1989;revised October 10, 1989 Flow-suppressed FLASH MR images of the human heart have been recorded within a measuring time of 0.3 s using a 2.0-T whole-body research system (Siemens Magnetom) equipped with a conventional 10 mT m-’ gradient system. Subsecond imaging times have been achievedby reducing the repetition time to TR = 4.8 ms and by loweringthe spatial resolution to 64 X 128measured data points. The flip angle of the slice-selective radiofrequency (rf)pulses was adjusted to lo”.Cardiac chambers, ventricular walls, and valves are well delineated in images from a single cardiac cycle using a field of view of 250 mm and a slicethicknessof 8mm. No motion artifactswere observedas a consequenceof the short echo time of TE = 2.8 ms. Distinction between flowing blood and solid struc- tures has been achievedby spatial presaturation ofadjacent slices using two slice-selective 90” rf pulses preceding the entire imaging sequence. 0 1990Academic Press, Inc. INTRODUCTION Functional investigationsof the heart represent the most challenging application of magnetic resonance imaging (MRI) as they simultaneously require high spatial resolution and time resolution. While conventional ECG-synchronized spin-echo MRI sequences offer excellent static anatomicaldetails at the expense of considerable measuring times, see, e.g., (I),dynami