原创力文档KIOM 79 prevents xylose induced lens opacity and inhibits TGF beta2 in human lens epithelial cells cultured under high glucose英文文献.pdfVIP
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Journal of Ethnopharmacology 130 (2010) 599–606
Contents lists available at ScienceDirect
Journal of Ethnopharmacology
j o u rn al h omepage: w w w. elsev /locate/jethpharm
KIOM-79 prevents xylose-induced lens opacity and inhibits TGF-beta2
in human lens epithelial cells cultured under high glucose
Nan Hee Kim 1, Young Sook Kim 1, Dong Ho Jung, Jin Sook Kim ∗
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM),
483 Exporo, Yuseong-gu, Daejeon 305-811, Republic of Korea
a r t i c l e i n f o a b s t r a c t
Article history: Aim of the study: To investigate the effects of KIOM-79 in preventing the development of diabetic com-
Received 23 February 2010 plications, such as cataracts.
Received in revised form 14 May 2010 Materials and methods: The inhibitory effects of KIOM-79 were assessed in a model of xylose-induced
Accepted 25 May 2010
lens opacity and on changes mediated by high levels of glucose in human lens epithelial (HLE-B3) cells.
Available online 1 June 2010
Results: In lenses treated with KIOM-79, opacity was significantly improved and glutathione (GSH) was
increased compared to controls. In HLE-B3 cells treated with KIOM-79, high glucose-mediated increases
Keywords:
in TGF-2, B-crystallin, and fibronectin were significantly inhibited in a dose-dependent manner. KIOM-
KIOM-79
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