The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses英文文献.pdfVIP

Immunity Review The Multifaceted Influence of the Mucosal Microflora on Mucosal Dendritic Cell Responses Warren Strober1,* 1Mucosal Immunity Section, Laboratory of Host Defenses, NIAID, NIH Bethesda, MD *Correspondence: wstrober@niaid.nih.gov DOI 10.1016/j.immuni.2009.09.001 Over the last decade, it has become apparent that the complex interactions between components of the mucosal microflora and the mucosal immune system can involve either direct contact with dendritic cells in the lamina propria or, alternatively, contact with epithelial cells lining the mucosa that then influence the function of dendritic cells. Although in some cases these interactions involve signaling specific to particular organisms and in others, to classes of organisms, a common theme is that signaling is invariably channeled through receptors that address many organisms or all organisms such as the pattern-recognition receptors TLR and NLR. Here, I review this information with the intention of identifying how the mucosal microflora influ- ences specific functions of the mucosal immune system such the production of particular cytokines as well as broader functions such as the maintenance of mucosal immune homeostasis and host defense. Introduction CX3CR1 DC subset contains the cells that respond to oral anti- In this review, I will consider some of the main mechanisms by gens (or luminal bacteria) and that then migrate to local draining which bacteria in the gastrointestinal tract (hereafter called the nodes where they present these antigens to T cells (Coombes microflora) communicate with and influence mucosal cytokine et al., 2007; Jaensson et al., 2008). Their expression of CD103, responses through their direct or indirect interactions with a ligand of E-cadherin expressed by epithelial cells, may facili- mucosal dendritc cells (DCs). As a preamble to this discussion ta