Occult hepatitis B virus infection a covert operation英文文献.pdfVIP

Journal of Viral Hepatitis, 2010, 17, 1–15 doi:10.1111/j.1365-2893.2009.01245.x Occult hepatitis B virus infection: a covert operation F. B. Hollinger and G. Sood Baylor College of Medicine, Houston, TX, USA Received September 2009; accepted for publication November 2009 SUMMARY. Detection of occult hepatitis B requires assays of HBV DNA with the most sensitive assay available. If a liver the highest sensitivity and specificity with a lower limit of biopsy is available, immunostaining for hepatitis B surface detection of less than 10 IU/mL for hepatitis B virus (HBV) antigen (HBsAg) and hepatitis B core antigen (HBcAg) DNA and 0.1 ng/mL for hepatitis B surface antigen should be contemplated and a portion of the sample tested (HBsAg). This covert condition is relatively common in for HBV DNA. This is another reason for optimal collection patients with chronic hepatitis C virus (HCV) that seems to of a specimen (e.g. two passes with a 16-guage needle exert some influence on the replicative capacity and under ultrasound guidance). Transmission of HBV to latency of HBV. Detection of virus-specific nucleic acid immunosuppressed orthotopic liver transplant recipients by does not always translate into infectivity, and the occur- donors with occult hepatitis B (OHB) will continue to rence of primer-generated HBV DNA that is of partial occupy the interests of the transplant hepatologist. As genomic length in immunocompetent individuals who patients with OHB may have detectable HBV DNA in have significant levels of hepatitis B surface antibody (anti- serum, peripheral blood mononuclear