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Post-Transcriptional Control: mRNA Translation, Localization and Turnover 1565
The involvement of microRNAs in Type 2
diabetes
1
David Ferland-McCollough* , Susan E. Ozanne†, Kenneth Siddle†, Anne E. Willis* and Martin Bushell*
*Medical Research Council Toxicology Unit, Hodgkin Building, University Leicester of Leicester, Leicester LE1 9HN, U.K., and †University of Cambridge
Metabolic Research Laboratories, Level 4, Institute of Metabolic Science, Box 289, Addenbrooke’s Hospital, Cambridge CB2 0QQ, U.K.
Abstract
T2D (Type 2 diabetes mellitus) is a major health issue that has reached epidemic status worldwide. T2D is a
progressive metabolic disorder characterized by reduced insulin sensitivity, insulin resistance and pancreatic
g β -cell dysfunction. Improper treatment of TD2 can lead to severe complications such as heart disease,
r stroke, kidney failure, blindness and nerve damage. The aetiology and molecular mechanisms of T2D are
o not fully understood, but compelling evidence points to a link between T2D, obesity, dyslipidaemia and
.
s insulin resistance. Although T2D seems to be strongly linked to environmental factors such as nutrition
n and lifestyle, studies have shown that genetic factors, such as polymorphisms associated with metabolic
a genes, imprinting, fetal programming and miRNA (microRNA) expression, could also contribute to the
r
t development of this disease. miRNAs are small 22–25-nt-long untranslated RNAs that negatively regulate
c the translation of mRNAs. miRNAs are involved in a large number of
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