TRAIL Induced Apoptosis Between Tumor Therapy and Immunopathology英文文献.pdfVIP

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS TRAIL-Induced Apoptosis Between Tumor Therapy and Immunopathology Nadia Corazza, Daniela Kassahn, Sabine Jakob, Anastasia Badmann, and Thomas Brunner Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland The death ligand members of the tumor necrosis factor (TNF) family are potent inducers of apoptosis in a variety of cell types. In particular, TNF-related apoptosis-inducing lig- and (TRAIL) has recently received much scientific and commercial attention because of its potent tumor cell-killing activity while leaving normal untransformed cells mostly unaffected. Furthermore, TRAIL strongly synergizes with conventional chemothera- peutic drugs in inducing tumor cell apoptosis, making it a most promising candidate for future cancer therapy. Increasing evidence indicates, however, that TRAIL may also induce or modulate apoptosis in primary cells. A particular concern is the potential side effect of TRAIL-based tumor therapies in the liver. In this review we summarize some of the recent findings on the role of TRAIL in tumor cell and hepatocyte apoptosis. Key words: TRAIL; hepatocyte; apoptosis; tumor; liver injury; Bim; Jun kinase Introduction and ultimately induce apoptosis. However, sev- eral tumor cells have developed various apop- To preserve proper physiological functions tosis resistance mechanisms, rendering many of multicellular organisms, the total number of of these treatments ineffective. Thus, alterna- cells must be tightly controlled. The absolute