Specificity of the autologous neutralizing antibody response英文文献.pdfVIP

Specificity of the autologous neutralizing antibody response Penny L. Moorea,b, Elin S. Graya,b and Lynn Morrisa,b aAIDS Virus Research Unit, National Institute for Purpose of review Communicable Diseases, Johannesburg and bCentre It has long been known that autologous neutralizing antibodies (AnAbs) exert pressure for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa on the envelope of HIV, resulting in neutralization escape. However, recently, progress Correspondence to Dr Penny L. Moore, National has been made in uncovering the precise targets of these potent early antibodies. Institute for Communicable Diseases, Private Bag X4, Recent findings Sandringham 2131, Johannesburg, South Africa AnAbs primarily target variable regions of the HIV-1 envelope, explaining the strain- Tel: +27 11 386 6331; fax +27 11 386 6453; e-mail: pennym@nicd.ac.za specificity of these antibodies. Despite high neutralizing potential and cross-reactivity, Current Opinion in HIV and AIDS 2009, anti-V3 antibodies do not contribute to autologous neutralization. The V1V2 is 4:358–363 commonly immunogenic in early HIV-1 and simian human immunodeficiency virus infections, though the nature of these epitopes remains to be determined. In subtype C viruses, the C3 region is a neutralization target, possibly as a result of its more exposed and amphipathic structure. Autologous neutralization appears to be mediated by very few AnAb specificities that develop sequentially suggesting the possibility of immunological hierarchies for both binding and neutraliz