新型抗过敏药英文版讲解课件.pptxVIP

抗过敏药 Antiallergic drug Flower?我在花粉的刺激下脓包成堆你在春天的花朵里自拍纷飞Content:1.Allergy disease and histamine2.The development of antiallergic drug3.New allergy medicine--Olopatadine Hydrochloride4.The chemical structure5.Structure-activity relationship(SAR)6.Study on toxicity and side effect7.Indications8.Synthetic route9.Prospects10.How to choose the allergy medicine?1.Allergy disease and histamineWhen body has been stimulated by the antigenic substances, it may be cause the tissue damage or physical disorders, namely pathological immune response to diseases.Histamine in inflammation and allergic diseases play an important role in physi-ological, histamine of proinflammatory and immune adjustment is by three kind-s of histamine H1,H2, H3.Histamine is the most important medium allergic disease.2.The development of antiallergic drugAntiallergic drugs are also called antihistamines, with the continuous development of pharmacology, antihistamines have been developed to six categories nearly hundred kinds of varieties.The first generation of antiallergic drugThe first generation of histamine H1 receptor antagonist has strong central nervous calming and choline fighting effects.The second generation of antiallergic drugThe advantages of second generation antiallergic:(1)better clinical curative effect (2)long-term effect(3)no side effect to central nervous system (4)no resisting choline effect(5)eutherapeutic to asthma (6)good tolerabilitySlightly CNS effect:①Sleepiness②headache③ whet the appetite and side effect to cardiovascular system3.New allergy medicine--Olopatadine Hydrochloride Olopatadine as a new kind of relatively high selectivity antiallergic, Concorde Fermentation by Japan listed company development and antiallergic, successively on the market in Europe, America, Japan and other countries.4.The chemical structure11-[(反)-3-二甲胺基丙烯]-6,11-二氢苯骈[b,e]氧杂卓-2-乙酸 盐酸Structure-activity relationship(SAR):1.烯基碳和氮原子间相隔2个碳原子最佳,延长或缩短碳链对H1受体的亲和力减弱;氮原子上以二甲基取代抑制支气管哮喘作用最强,以二乙基取代抑制作用减弱,以吗琳