第7章 细胞内膜系统蛋白质分选与膜泡系统PPT
Two pathways for exocytosis: regulated and constitutive 溶酶体(lysosome) ◆溶酶体 (Lysosome)于1955年由de Duve和Novikoff 发现 ◆呈小球状,大小变化很大,直径一般在0.25~0.8uM之间 ◆ 膜有质子泵,溶酶体内pH值低 ◆含有50多种酸性水解酶类(最适pH=5) ,在细胞内起消化和保护作用 ◆当细胞被损伤时,溶酶体可释放出水解酶类,使细胞自溶 ◆Primary degradative organelle ◆Degrades proteins, lipids and other cellular constituents taken in by endocytosis(胞吞), phagocytosis (吞噬作用), and autophagy (自体吞噬) Pathways to lysosomal degradation 溶酶体(lysosome) Transport from the trans Golgi network (TGN) to lysosomes The lysosome The endpoint of the endocytosis pathway for many molecules is the lysosome, a highly acid
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