病毒性肝炎教学教材.pptVIP

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实验室检查 (一)肝功能检查 血清酶的检测 血清蛋白的检测 血清和尿胆色素检测 凝血酶原时间检测 血氨浓度检测 实验室检查 (二)肝炎病毒标记物检测 (三)肝组织学检查 (四)影象学检查 (五)血尿常规 Laboratory Diagnosis of HBV HBV antigen-antibody system. HBV-DNA - various techniques are available e.g. PCR and branched DNA. May be used to diagnose HBV infection in the acute phase. However, its main use is in monitoring the response to antiviral therapy. HBV DNA-P Laboratory Diagnosis of HCV HCV antibody - generally used to diagnose hepatitis C infection. Not useful in the acute phase as it takes at least 4 weeks after infection before antibody appears. HCV-RNA - various techniques are available e.g. PCR and branched DNA. May be used to diagnose HCV infection in the acute phase. However, its main use is in monitoring the response to antiviral therapy. HCV-antigen - an EIA for HCV antigen is available. It is used in the same capacity as HCV-RNA tests but is much easier to carry out. Viral hepatitis:Diagnosis 流行病学资料 临床资料(症状,体征,实验室检查) 病原学诊断 病理学诊断 Viral hepatitis: Differential Diagnosis 其他原因引起的黄疸 溶血性黄疸  肝外梗阻性黄疸 其他原因引起的ALT肝炎 其他病毒引起的肝炎 感染中毒性肝炎 药物引起的肝炎 酒精性肝病 血吸虫性肝病 其他肝病 PBC,AIH,Wilson 病 Viral hepatitis:Prognosis Symptomatic Infection Chronic Infection Age at Infection Chronic Infection (%) Symptomatic Infection (%) Birth 1-6 months 7-12 months 1-4 years Older Children and Adults 0 20 40 60 80 100 100 80 60 40 20 0 Outcome of Hepatitis B Virus Infection by Age at Infection Chronic Infection (%) High (8%): 45% of global population lifetime risk of infection 60% early childhood infections common Intermediate (2%-7%): 43% of global population lifetime risk of infection 20%-60% infections occur in all age groups Low (2%): 12% of global population lifetime risk of infection 20% most infections occur in adult risk groups Global Patterns of Chronic HBV Infection High Moderate Low/Not Detectable blood semen urine serum vaginal fluid feces wound exudates saliva sweat tears breastmilk Concentration of Hepatitis B Virus in Various Body Fluids

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