小剂量红霉素对COPD稳定期患者免疫功能的干预研究.doc

小剂量红霉素对COPD稳定期患者免疫功能的干预研究▲ 邵有和 陈昌枝 覃淑娟 吴文彬 覃家盟 广西医科大学第八附属医院暨广西贵港市人民医院呼吸内科（广西，贵港，537100） 摘要 目的 探讨小剂量红霉素对COPD稳定期患者免疫功能的干预效果。方法 选取慢性阻塞性肺疾病稳定期患者86例分为观察组和对照组各43例。在对照组常规治疗的基础上观察组加用小剂量红霉素治疗3个月。结果 观察组患者治疗后的6MWD、FEV1和CD3+、CD4+、CD4+/CD8+以及IgA、IgG明显高于对照组，MMRC、CD8+和CRP明显低于对照组，差异有统计学意义（P0.05）；观察组患者治疗后的6MWD、FEV1和CD3+、CD4+、CD4+/CD8+以及IgA、IgG明显高于治疗前，MMRC、CD8+和CRP明显低于治疗前，差异有统计学意义（P0.05）。结论 慢性阻塞性肺疾病患者长期使用小剂量红霉素，可增强其免疫功能，改善其临床症状、肺功能及运动耐力。 关键词：慢性阻塞性肺疾病；稳定期；T淋巴细胞；免疫球蛋白；肺功能；6min步行距离；呼吸困难量表 intervention study of low-dose erythromycin on the immune fuction of stable COPD patients Shao you-he，Chen chang-zhi，Qin shu-juan，WU wen-bin，Qin jia-meng (Department of Respiratory medicine，Guigang City People′s Hospital，The Eighth Affiliated Hospital of Guangxi medical University，Guigang 537100，China) 【Abstract】ObjectiveTo investigate the effects of low-dose erythromycin stable immune function in COPD patients.Methods Selected patients with stable chronic obstructive pulmonary disease 86 cases divided into observation group and the control group 43 cases. On the basis of the control group were observed conventional treatment group were treated with low-dose erythromycin treatment three months.Results6MWD observation group after treatment, FEV1, and CD3+, CD4+, CD4+/CD8+ and IgA, IgG was significantly higher, MMRC，CD8+ andCRPwas significantly lower than the control group, the difference was statistically significant (P0.05)；6MWD was observed in patients after treatment, FEV1, and CD3+, CD4+, CD4+/CD8+ and IgA, IgG was significantly higher than before treatment, MMRC，CD8+andCRP was significantly lower than before treatment, the difference was statistically significant (P0.05).ConclusionLong-term low-dose erythromycin, can be adjusted with chronic obstructive pulmonary disease patients with stable immune function, improve lung function, symptoms and exercise tolerance. 【Key words】 chronic obstructive pulmonary disease；Stable；T lymphocytes； immunoglobulin；lung function；6min walking distance；dyspnea scale