氯过氧化物酶在手性有机合成中的应用3.PDF

第 18 卷 第 9 期 化　学　进　展 Vol. 18 No. 9 2006 年 9 月 PROGRESS IN CHEMISTRY 　Sep. , 2006 氯过氧化物酶在手性有机合成中的应用 智丽飞　蒋育澄 　胡满成　李淑妮 ( 陕西师范大学化学与材料科学学院 　西安 710062) ( ) 摘　要 　氯过氧化物酶 CPO 作为过氧化物酶家族中的一员对多种有机底物表现出了广泛的催化活 性。自上世纪 60 年代被发现以来 ,CPO 在有机合成中的应用一直是一个研究热点。它作为一种生物催化剂 能催化广泛的底物合成手性化合物 ,且有高的产率和高的对映选择率。本文综述了氯过氧化物酶在手性有 机合成中的应用 ,重点关注了卤化、醇氧化、羟基化、环氧化、磺化氧化等反应 ,并讨论了目前在该领域所面临 的问题及今后的发展趋势。 关键词 　氯过氧化物酶 　对映选择性 　环氧化 　羟基化 　磺化氧化 + ( ) 中图分类号: O6213 ; Q554 6 　文献标识码 : A 　文章编号 : 1005281X 2006 Applications of Chloroperoxidase in Chiral Organic Synthesis Zhi Lifei 　Jiang Yucheng 　Hu Mancheng 　Li Shuni ( School of Chemistry and Materials Science , Shaanxi Normal University , Xi’an 710062 , China) Abstract 　Chloroperoxidase ( CPO) as a member of peroxidase family has extensive catalytic activities for various organic substrates. Applications of CPO in organic synthesis has been and will still be a research hotspot , since it was discovered in 1960s. However , the most interest characteristic of the CPO is the chiral catalytic activity performed in the asymmetric synthesis which is related to its unique structure. CPO as a biocatalyst for wide range of substrates to chiral compounds with high yield and enantioselectivity has been studied. In this paper , applications of chloroperoxidase in chiral organic synthesis are introduced. The focuses are especially on halogenation , oxidation of alcohols , hydroxylation , epoxidation and sulfoxidation reactions. The proble