基因指导社区高血压精细管理_周慧君演示幻灯片.pptVIP

Selected genes affecting hypertension drug metabolism: Candidate Gene Selection CYP2C9*3 CYP2C19*2/*3 CYP2D6*10 与中国疾控中心及武汉市卫生局合作， 我们在武汉五个社区医疗中心挑选了350个原发性高血压患者，并确定了这些患者的P450基因的基因型，随后我们对基因型与降压药物的反应做了关联分析。 Patient Selection Age: 37-71 years old Gender: men and women, half and half Sample collection: blood Processes genotyping DNA preparation Sample collection bioinformatics analysis reports Genotype Frequency Genotype Results Frequency Allele RESULT Gene Genotype Phenotype CYP2C9*3 AA Normal Metabolizer CYP2D6 *10 TT Poor Metabolizer CYP2C19*2 GG Normal Metabolizer CYP2C19*3 GG Norm